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突发食管坏死并纵隔炎与侵袭性念珠菌病相关:一例报告。

Sudden Esophageal Necrosis and Mediastinitis Associated with Invasive Candidiasis: A Case Report.

机构信息

Department of Emergency Medicine, Universidad ICESI (ICESI University), Cali, Colombia.

Department of Emergency, Fundación Valle del Lili, Cali, Colombia.

出版信息

Am J Case Rep. 2021 Jun 28;22:e928394. doi: 10.12659/AJCR.928394.

DOI:10.12659/AJCR.928394
PMID:34181635
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8255081/
Abstract

BACKGROUND Esophageal necrosis is a rare entity characterized by the presence of extensive circumferential necrosis of the esophagus. It generally affects older adults who have associated chronic pathologies and has a reported mortality rate of approximately 32%. Most patients with esophageal necrosis have a complex clinical course. CASE REPORT We present the case of a 37-year-old man with idiopathic chronic renal failure who presented to the Emergency Department with sudden esophageal necrosis and mediastinitis, associated with invasive candidiasis. Diagnosis was challenging owing to the rarity of the condition. The patient required intensive care management and multiple surgical procedures. CONCLUSIONS Esophageal necrosis is an uncommon pathology that can be fatal because of associated complications. Its pathophysiology is unclear, and its treatment is based on the control of local injury and signs and symptoms. Acute esophageal necrosis associated with invasive Candida sp. infection is even more infrequent, with only a few cases reported in the literature.

摘要

背景

食管坏死是一种罕见的疾病,其特征是食管广泛的环状坏死。它通常影响有伴随慢性疾病的老年患者,死亡率约为 32%。大多数患有食管坏死的患者有复杂的临床病程。

病例报告

我们介绍了一位 37 岁的男性患者,患有特发性慢性肾衰竭,因突发食管坏死和纵隔炎,合并侵袭性念珠菌病,到急诊科就诊。由于这种情况很少见,因此诊断具有挑战性。该患者需要重症监护管理和多次手术。

结论

食管坏死是一种罕见的可能因相关并发症而致命的疾病。其病理生理学尚不清楚,治疗基于局部损伤和症状的控制。急性食管坏死合并侵袭性念珠菌感染更为罕见,文献中仅报道了少数几例。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e843/8255081/2e61ce768fc4/amjcaserep-22-e928394-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e843/8255081/b191f544977b/amjcaserep-22-e928394-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e843/8255081/6d8918f756ef/amjcaserep-22-e928394-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e843/8255081/2e61ce768fc4/amjcaserep-22-e928394-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e843/8255081/b191f544977b/amjcaserep-22-e928394-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e843/8255081/6d8918f756ef/amjcaserep-22-e928394-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e843/8255081/2e61ce768fc4/amjcaserep-22-e928394-g003.jpg

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Clin Gastroenterol Hepatol. 2021 Feb;19(2):e16. doi: 10.1016/j.cgh.2019.12.039. Epub 2020 Jan 9.
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Diagnosis and management of acute esophageal necrosis.急性食管坏死的诊断与处理
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Acute Esophageal Necrosis: A View in the Dark.急性食管坏死:黑暗中的视角
Case Rep Gastroenterol. 2019 Jan 16;13(1):25-31. doi: 10.1159/000496385. eCollection 2019 Jan-Apr.
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Fatal necrotizing esophagitis in a patient with leukocytoclastic cutaneous vasculitis and ankylosing spondylitis.一名患有白细胞破碎性皮肤血管炎和强直性脊柱炎的患者发生致命性坏死性食管炎。
Autops Case Rep. 2019 Mar 22;9(2):e2018070. doi: 10.4322/acr.2018.070. eCollection 2019 Apr-Jun.
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Expert Rev Gastroenterol Hepatol. 2019 May;13(5):507-514. doi: 10.1080/17474124.2019.1601555. Epub 2019 Apr 16.
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