Tripathy Archana, Swain Nitish, Gupta Bhawna
Disease Biology Laboratory, School of Biotechnology, Kalinga Institute of Industrial Technology (KIIT) deemed to be University, Bhubaneswar, Odisha, 751024, India.
Future Virol. 2021 Jun. doi: 10.2217/fvl-2020-0393.
COVID-19 is a respiratory infection similar to viral pneumonia and is caused by SARS-CoV-2. Chloroquine and hydroxychloroquine make up the major part of the treatment regimen for the management of COVID-19 infections, which are also commonly used in treatment of patients with malaria as well as autoimmune diseases like rheumatoid arthritis (RA). In this review, we analyzed the scientific evidences pertaining to any possible association of SARS-CoV-2 infection with RA. We thus believe that people predisposed to RA carry a higher infection risk than the general population both due to the iatrogenic effects of the RA related drug therapy. Thus COVID-19 pandemic may bring a higher risk of health emergency in complex diseases such as RA.
新冠病毒病(COVID-19)是一种类似于病毒性肺炎的呼吸道感染疾病,由严重急性呼吸综合征冠状病毒2(SARS-CoV-2)引起。氯喹和羟氯喹构成了COVID-19感染治疗方案的主要部分,它们也常用于治疗疟疾患者以及类风湿性关节炎(RA)等自身免疫性疾病。在本综述中,我们分析了与SARS-CoV-2感染和RA之间任何可能关联相关的科学证据。因此我们认为,由于RA相关药物治疗的医源性影响,易患RA的人群比普通人群具有更高的感染风险。因此,COVID-19大流行可能给RA等复杂疾病带来更高的健康紧急风险。