Camporro Fernando Astur, Kevorkof Gregorio Varujan, Gallmann Ana, Gazzoni Florencia, Bulacio Exequiel, Gutierrez Magaldi Ignacio, Borsini Eduardo
Clinica Universitaria Reina Fabiola.
Servicio de Neumonología, Clínica Universitaria Reina Fabiola.
Rev Fac Cien Med Univ Nac Cordoba. 2021 Jun 28;78(2):137-141. doi: 10.31053/1853.0605.v78.n2.30397.
Intermittent chronic hypoxia produced during obstructive sleep apneas (OSA) leads to oxidative stress, and consequently to a state of systemic inflammation. There are no biomarkers that assess the degree of inflammation and are related to the severity of this disease. The red cell distribution amplitude and the ultrasensitive reactive C protein are sensitive to the systemic inflammation generated by oxidative stress. We intend to correlate the reactive C protein and red cell distribution amplitude values with the degree of severity of OSA.
An observational, prospective, analytical study was performed. OSA patients participated. Spearman's correlation coefficient was used to estimate the correlation between red cell distribution amplitude and reactive C protein with OSA severity according to apnea hypopnea index (AHI).
95 patients participated, of which 79 were men. Only 10 (10.5%) patients presented normal BMI. The correlations between AHI with reactive C protein and red cell distribution amplitude were weak (r = 0.17; p = 0.1066 and r = 0.06; p = 0.5867, respectively). The correlations between T90 with reactive C protein and red cell distribution amplitude were also weak (r = 0.16; p = 0.1331 and r = 0.24; p = 0.0202, respectively). An association was found between red cell distribution amplitude greater than 14 and severe OSA (p = 0.0369) and with T90 greater than 10% (p = 0.0168).
Although the correlations between AHI and T90 with reactive C protein and red cell distribution amplitude were weak, it was found that severe patients, presented higher values of red cell distribution amplitude and higher T <90. This association could not be tested with reactive C protein.
阻塞性睡眠呼吸暂停（OSA）期间产生的间歇性慢性缺氧会导致氧化应激，进而引发全身炎症状态。目前尚无评估炎症程度且与该疾病严重程度相关的生物标志物。红细胞分布宽度和超敏C反应蛋白对氧化应激产生的全身炎症敏感。我们旨在将C反应蛋白和红细胞分布宽度值与OSA的严重程度相关联。
进行了一项观察性、前瞻性分析研究。纳入OSA患者。根据呼吸暂停低通气指数（AHI），使用Spearman相关系数估计红细胞分布宽度和C反应蛋白与OSA严重程度之间的相关性。
95名患者参与研究，其中79名男性。只有10名（10.5%）患者BMI正常。AHI与C反应蛋白和红细胞分布宽度之间的相关性较弱（分别为r = 0.17；p = 0.1066和r = 0.06；p = 0.5867）。T90与C反应蛋白和红细胞分布宽度之间的相关性也较弱（分别为r = 0.16；p = 0.1331和r = 0.24；p = 0.0202）。发现红细胞分布宽度大于14与重度OSA相关（p = 0.0369），且与T90大于10%相关（p = 0.0168）。
尽管AHI和T90与C反应蛋白和红细胞分布宽度之间的相关性较弱，但发现重度患者的红细胞分布宽度值和T<90较高。这种关联无法用C反应蛋白进行检验。
