Izutsu T, Kagabu T, Nishiya I, Wied G L
Department of Obstetrics and Gynecology, Iwate Medical University, Morioka.
Nihon Sanka Fujinka Gakkai Zasshi. 1988 Jul;40(7):909-14.
DNA analyses of nuclei of squamous cells on 86 cases with squamous cells carcinoma of the uterine cervix, who had been treated with radiotherapy, were studied in 95 specimens. Forty-three specimens taken from invasive cancer cases before radiotherapy and 52 smears taken from the patients with cervical cancer after radiotherapy were examined by rapid high-resolution cytometry. The biologic behavior in this retrospective study was known, and the cases were classified into "poor" and "good" prognostic groups depending on their five year survival rates. In the poor prognostic group, the smears taken prior to radiotherapy showed a significantly lower 5N-exceeding rate (5NER) and a smaller Nuclear area than did those of the good prognostic group. The smears taken from the cases of recurrent cancer and postradiation dysplasia with poor prognosis showed significantly lower 5NER and a smaller Nuclear area than did those from cases of postradiation dysplasia and radiation changes in patients with a good prognosis after radiotherapy.
对86例接受过放射治疗的子宫颈鳞状细胞癌患者的鳞状细胞核进行了DNA分析，共研究了95个标本。对43个放疗前取自浸润癌病例的标本和52个放疗后取自宫颈癌患者的涂片进行了快速高分辨率细胞计数检查。在这项回顾性研究中，生物学行为是已知的，根据五年生存率将病例分为“预后差”和“预后好”两组。在预后差的组中，放疗前采集的涂片显示5倍体超过率（5NER）显著较低，核面积比预后好的组小。取自复发癌和预后差的放疗后发育异常病例的涂片显示5NER显著较低，核面积比取自放疗后预后好的患者的放疗后发育异常和放射改变病例的涂片小。
