Department of Movement, Human and Health Sciences, University of Rome "Foro Italico", Rome, Italy.
Department of Experimental and Clinical Medicine, University of Catanzaro "Magna Græcia", Catanzaro, Italy.
Curr Opin Pharmacol. 2021 Aug;59:95-102. doi: 10.1016/j.coph.2021.05.006. Epub 2021 Jun 26.
Physical inactivity and sedentary behavior are risk factors for type 2 diabetes mellitus (T2DM). Therefore, physical exercise (PE) together with medical treatment might be considered as a key strategy to counteract T2DM. Glycemic control is a central objective in the prevention and management of T2DM, and PE might be able to substantially affect the processes that determine it. Just like a drug, exercise can be dosed based on the characteristics of the individual to increase its benefits and reduce side effects. In this brief review, the mechanisms underlying the effects of PE on glucose metabolism in muscle are illustrated, and the effects of modulation of the parameters characterizing this atypical "drug" on glucose homeostasis are described.
身体活动不足和久坐行为是 2 型糖尿病（T2DM）的危险因素。因此，体育锻炼（PE）与医学治疗一起可能被认为是对抗 T2DM 的关键策略。血糖控制是预防和管理 T2DM 的中心目标，PE 可能能够显著影响决定血糖的过程。就像药物一样，运动可以根据个体的特点进行剂量调整，以增加其益处并减少副作用。在这篇简要的综述中，说明了 PE 对肌肉葡萄糖代谢影响的机制，并描述了调节这种非典型“药物”特征参数对葡萄糖稳态的影响。
