膳食钙摄入对肥胖小鼠的复杂调节作用。
Complex Modulating Effects of Dietary Calcium Intake on Obese Mice.
机构信息
Division of Prevention, Center for Public Health Sciences, National Cancer Center, Tokyo, Japan.
Department of Molecular-Targeting Prevention, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.
出版信息
In Vivo. 2021 Jul-Aug;35(4):2107-2114. doi: 10.21873/invivo.12480.
BACKGROUND/AIM: Οverweight and obesity are risk factors for chronic diseases. Dietary calcium has been reported to exert anti-obesity effects. However, the complex modulating effects of calcium intake on obese mice have not been clarified.
MATERIALS AND METHODS
The effects of calcium intake on body weight/visceral fat mass were examined in the obese mouse model, KK-A Results: Body weight gain decreased in mice fed a diet containing 0.4 to 3.2% calcium at the age of 11 and 13 weeks, but not at 12 weeks after normalization for food intake. Calcium intake also decreased serum insulin levels and increased the amount of feces excreted. Fecal deoxycholate levels were lower in the high-calcium group than in the normal diet control group. Furthermore, the ratio of the deoxycholate-producing microbiome in feces decreased.
CONCLUSION
Dietary calcium has anti-obesity effects in obese KK-A mice. Inhibition of insulin production and an increased amount of feces excreted with calcium intake may affect body weight.
背景/目的：超重和肥胖是慢性病的危险因素。有报道称膳食钙具有抗肥胖作用。然而，钙摄入对肥胖小鼠的复杂调节作用尚未阐明。
材料和方法
在肥胖小鼠模型 KK-A 中，研究了钙摄入对体重/内脏脂肪量的影响。
结果
在 11 周和 13 周时，摄入含有 0.4%至 3.2%钙的饮食可减少小鼠的体重增加，但在 12 周时，通过对食物摄入量进行归一化后，体重增加没有减少。钙摄入还降低了血清胰岛素水平并增加了粪便排泄量。高钙组的粪便脱氧胆酸水平低于正常饮食对照组。此外，粪便中产脱氧胆酸微生物组的比例降低。
结论
膳食钙对肥胖 KK-A 小鼠具有抗肥胖作用。钙摄入可能通过抑制胰岛素产生和增加粪便排泄量来影响体重。
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