输尿管芽衍生物在威尔姆斯瘤和肾发育不良中的作用
Ureteric Bud-derivatives in Wilms Tumor and Nephrogenic Rest.
机构信息
Department of Urology, Medical School, University of Pecs, Pecs, Hungary.
Medical Faculty, Ruprecht-Karls-University, Heidelberg, Germany.
出版信息
In Vivo. 2021 Jul-Aug;35(4):2159-2162. doi: 10.21873/invivo.12486.
BACKGROUND/AIM: Recent studies suggest that not only the nephrogenic blastema but also the ureteric bud is involved in oncogenesis of Wilms' tumor (WT). However, the occurrence of ureteric bud (UB) derivatives in nephrogenic rest is not yet known. The aim of our study was to find UB derivatives in WT.
MATERIALS AND METHODS
Keratin 17 (KRT17) is expressed exclusively in UB in foetal kidneys. In this study KRT17 immunohistochemistry was used to detect UB-derivatives in 21 triphasic, 2 stromal and 3 epithelial predominant WTs and 9 nephrogenic rests.
RESULTS
We have detected KRT17 positive tubular structures resembling UB in 3 of 9 nephrogenic rests and 15 of 26 WTs.
CONCLUSION
Not only the metanephric blastema but also the UB is involved in the histogenesis of nephrogenic rest and WT.
背景/目的：最近的研究表明，不仅肾胚基，而且输尿管芽也参与了肾母细胞瘤（WT）的发生。然而，肾胚基残余中输尿管芽衍生物的发生尚不清楚。本研究的目的是在 WT 中寻找输尿管芽衍生物。
材料和方法
角蛋白 17（KRT17）在胎儿肾脏中仅表达于输尿管芽。在这项研究中，我们使用 KRT17 免疫组化来检测 21 例三时相、2 例间质和 3 例上皮优势的 WT 和 9 例肾胚基残余中的输尿管芽衍生物。
结果
我们在 9 例肾胚基残余中的 3 例和 26 例 WT 中的 15 例中检测到 KRT17 阳性的管状结构，类似于输尿管芽。
结论
不仅是后肾胚基，而且输尿管芽也参与了肾胚基残余和 WT 的组织发生。
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