MTA1 高表达预示着口腔鳞状细胞癌患者的生存预后不良。
High Expression of MTA1 Predicts Unfavorable Survival in Patients With Oral Squamous Cell Carcinoma.
机构信息
School of Medicine, Chung Shan Medical University, Taichung, Taiwan, R.O.C.
Department of Pathology, Changhua Christian Hospital, Changhua, Taiwan, R.O.C.
出版信息
In Vivo. 2021 Jul-Aug;35(4):2363-2368. doi: 10.21873/invivo.12513.
BACKGROUND/AIM: Metastasis-associated protein 1 (MTA1) plays a role in ATP-dependent nucleosome disruption activity and histone deacetylase activity and may indicate DNA methylation activity. MTA1 may also be involved in the progression of oral squamous cell carcinoma (OSCC).
PATIENTS AND METHODS
MTA1 immunoreactivity was analyzed using immunohistochemical (IHC) staining analysis in specimens from 281 OSCC patients. Kaplan-Meier analysis was used to determine the prognostic value of MTA1 for overall survival.
RESULTS
High MTA1 expression was significantly associated with female gender and lymph node metastasis. Multivariate analyses showed the independent prognostic role of high MTA1 expression in patients with OSCC of poorer mean survival.
CONCLUSION
MTA1 expression, detected by IHC staining, could be an independent prognostic marker for patients of OSCC.
背景/目的：转移相关蛋白 1（MTA1）在 ATP 依赖性核小体破坏活性和组蛋白去乙酰化酶活性中发挥作用，可能表明 DNA 甲基化活性。MTA1 也可能参与口腔鳞状细胞癌（OSCC）的进展。
患者和方法
使用免疫组织化学（IHC）染色分析在 281 例 OSCC 患者的标本中分析 MTA1 免疫反应性。使用 Kaplan-Meier 分析确定 MTA1 对总生存率的预后价值。
结果
高 MTA1 表达与女性和淋巴结转移显著相关。多变量分析显示，高 MTA1 表达在 OSCC 患者中的独立预后作用较差。
结论
通过 IHC 染色检测 MTA1 表达，可能成为 OSCC 患者的独立预后标志物。
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