Department of Gastroenterological Oncology, International Medical Center, Saitama Medical University, Saitama, Japan;
Department of Respiratory Medicine, International Medical Center, Saitama Medical University, Saitama, Japan;
In Vivo. 2021 Jul-Aug;35(4):2425-2432. doi: 10.21873/invivo.12520.
BACKGROUND/AIM: Little is known about the expression of L-type amino acid transporter 1 (LAT1) and 4F2hc in gastroenteropancreatic-neuroendocrine neoplasms (GEP-NENs). Hence, we conducted a study to verify the clinicopathological significance of LAT1 and 4F2hc.
Tissues from 126 patients with GEP-NENs were collected between August 2007 and August 2019 at our institution. We evaluated LAT1 and 4F2hc expression by immunohistochemistry, and examined their clinical significance.
No statistically significant associations were observed between LAT1 expression and the different NENs. Expression of 4F2hc was significantly different between neuroendocrine tumour (NET)-G1, NET-G2, and NET-G3 (p=0.029), and was significantly associated with vascular invasion (p=0.044) and the Ki-67 index (p=0.042).
No association between LAT1 expression and malignant features in GEP-NENs was observed. However, an association between 4F2hc expression and the potential of malignancy in GEP-NENs was evident.
背景/目的：关于 L 型氨基酸转运蛋白 1（LAT1）和 4F2 重链（4F2hc）在胃肠胰神经内分泌肿瘤（GEP-NENs）中的表达知之甚少。因此，我们进行了一项研究，以验证 LAT1 和 4F2hc 的临床病理意义。
本研究于 2007 年 8 月至 2019 年 8 月期间在我院收集了 126 名 GEP-NENs 患者的组织。我们通过免疫组织化学评估 LAT1 和 4F2hc 的表达，并检查其临床意义。
LAT1 表达与不同的 NENs 之间无统计学显著相关性。4F2hc 的表达在神经内分泌肿瘤（NET）-G1、NET-G2 和 NET-G3 之间存在显著差异（p=0.029），并与血管侵犯（p=0.044）和 Ki-67 指数（p=0.042）显著相关。
在 GEP-NENs 中未观察到 LAT1 表达与恶性特征之间存在关联。然而，在 GEP-NENs 中，4F2hc 表达与恶性潜能之间存在明显的关联。
