L 型氨基酸转运蛋白 1 表达在胰腺癌手术切除中的预后意义。
Prognostic significance of L-type amino-acid transporter 1 expression in surgically resected pancreatic cancer.
机构信息
Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Showa-machi, Maebashi, Gunma 371-8511, Japan.
出版信息
Br J Cancer. 2012 Aug 7;107(4):632-8. doi: 10.1038/bjc.2012.310. Epub 2012 Jul 17.
BACKGROUND
The expression of L-type amino-acid transporter 1 (LAT1) is tumour-specific and has been shown to have essential roles in cell growth and survival. However, little is known regarding the clinical significance of LAT1 expression in pancreatic cancer. This study was conducted to determine the prognostic significance of LAT1 expression.
METHODS
A total of 97 consecutive patients with surgically resected pathological stage I-IV pancreatic ductal adenocarcinoma were retrospectively reviewed. Tumour sections were stained by immunohistochemistry for LAT1, CD98, Ki-67 and vascular endothelial growth factor (VEGF), and microvessel density was determined by CD34 and p53.
RESULTS
L-type amino-acid transporter 1 and CD98 were highly expressed in 52.6% (51/97) and 56.7% (55/97) of cases, respectively (P=0.568). The expression of LAT1 within pancreatic cancer cells was significantly associated with disease stage, tumour size, Ki-67, VEGF, CD34, p53 and CD98. L-type amino-acid transporter 1 expression was confirmed to be a significant prognostic factor for predicting poor outcome by multivariate analysis.
CONCLUSION
L-type amino-acid transporter 1 expression is a promising pathological marker for the prediction of outcome in patients with pancreatic cancer.
背景
L 型氨基酸转运蛋白 1（LAT1）的表达具有肿瘤特异性，并且已被证明在细胞生长和存活中具有重要作用。然而，关于 LAT1 在胰腺癌中的表达的临床意义知之甚少。本研究旨在确定 LAT1 表达的预后意义。
方法
回顾性分析了 97 例连续接受手术切除病理分期 I-IV 期胰腺导管腺癌的患者。通过免疫组织化学染色检测 LAT1、CD98、Ki-67 和血管内皮生长因子（VEGF）的表达，并通过 CD34 和 p53 检测微血管密度。
结果
LAT1 和 CD98 在 52.6%（51/97）和 56.7%（55/97）的病例中高表达（P=0.568）。LAT1 在胰腺癌细胞中的表达与疾病分期、肿瘤大小、Ki-67、VEGF、CD34、p53 和 CD98 显著相关。多因素分析证实 LAT1 表达是预测胰腺癌患者不良预后的显著预后因素。
结论
LAT1 表达是预测胰腺癌患者预后的有前途的病理标志物。
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