药物治疗相关黄斑水肿伴全层黄斑裂孔的封闭
Closure of Full-Thickness Macular Holes Associated with Macular Edema with Medical Therapy.
作者信息
Kokame Gregg T, Johnson Mark W, Lim Jennifer, Flynn Harry W, de Carlo Talisa, Yannuzzi Nicolas, Ryan Edwin H, Omizo Jase N, Sridhar Jayanth, Staropoli Patrick, Goldhagen Brian, Lian Rebecca
机构信息
Division of Ophthalmology, Department of Surgery, University of Hawaii John A. Burns School of Medicine, Honolulu, Hawaii, USA.
Hawaii Macula and Retina Institute, Aiea, Hawaii, USA.
出版信息
Ophthalmologica. 2022;245(2):179-186. doi: 10.1159/000516018. Epub 2021 Jun 28.
PURPOSE
The purpose of this study was to report the closure of macular hole without surgery in 7 cases using medical therapies.
METHODS
The retrospective review of 7 cases of full-thickness macular holes, which closed after medical therapy without surgery.
RESULTS
Seven eyes of 7 patients developed full-thickness macular holes, which initially closed on medical therapy without surgery. Six patients were kept on maintenance therapy; 1 recurred and 5 did not develop recurrence. One patient was taken off of maintenance therapy and later developed recurrent macular hole requiring macular hole surgery.
CONCLUSIONS
Medical therapy to decrease macular edema may facilitate macular hole closure and should be considered, especially for small macular holes with significant edema. Reopening of macular holes may occur after stopping topical maintenance therapy for macular edema, which occurred at 10 weeks and 9 months after maintenance therapy was discontinued or markedly tapered.
目的
本研究旨在报告7例采用药物治疗而非手术实现黄斑裂孔闭合的病例。
方法
对7例经药物治疗而非手术治疗后闭合的全层黄斑裂孔病例进行回顾性分析。
结果
7例患者的7只眼出现了全层黄斑裂孔，最初经药物治疗而非手术治疗实现了闭合。6例患者持续接受维持治疗；1例复发，5例未复发。1例患者停止维持治疗，随后出现复发性黄斑裂孔，需要进行黄斑裂孔手术。
结论
减轻黄斑水肿的药物治疗可能有助于黄斑裂孔闭合，应予以考虑，尤其是对于伴有明显水肿的小黄斑裂孔。在停止用于黄斑水肿的局部维持治疗后，黄斑裂孔可能会重新开放，这种情况分别发生在维持治疗停止或显著减量后的10周和9个月。
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