Department of Medical Pharmacology, Faculty of Medicine, Cairo University, Giza, Egypt.
Department of Pharmacology and Therapeutics, College of Medicine, Jouf University, Sakaka, Saudi Arabia.
Pharmacology. 2021;106(9-10):564-572. doi: 10.1159/000516495. Epub 2021 Jun 28.
Recent studies highlighted the association of hyperuricemia and metabolic syndrome (MS). The aim of this study was to compare the beneficial effects of febuxostat versus allopurinol on the biochemical changes that occur in MS.
Forty adult male Sprague Dawley albino rats were used in the study. Insulin resistance and MS were induced by administration of a high-fructose diet for 8 weeks. Follow-up of changes in weight, blood pressure, serum biochemical parameters, serum antioxidant catalase, and glutathione peroxidase activities was done. At the end of the study, animals were sacrificed, and the thoracic aorta was isolated for in vitro study of the endothelial integrity.
Allopurinol and febuxostat treatment induced significant reduction in body weight, systolic blood pressure, blood glucose, insulin, lipids, and improved kidney functions and endothelial integrity compared to nontreated rats. Febuxostat was more effective than allopurinol in normalizing serum fasting glucose, uric acid, catalase, and glutathione peroxidase activities.
Xanthine oxidase inhibitors ameliorated the effects of MS. Febuxostat was mildly superior to allopurinol in lowering serum fasting glucose, lipids, uric acid, and antioxidant enzyme activities.
最近的研究强调了高尿酸血症与代谢综合征（MS）之间的关联。本研究的目的是比较非布司他与别嘌醇对 MS 发生的生化变化的有益影响。
本研究使用了 40 只成年雄性 Sprague Dawley 白化大鼠。通过给予高果糖饮食 8 周来诱导胰岛素抵抗和 MS。监测体重、血压、血清生化参数、血清抗氧化剂过氧化氢酶和谷胱甘肽过氧化物酶活性的变化。在研究结束时，处死动物并分离胸主动脉进行内皮完整性的体外研究。
与未治疗的大鼠相比，别嘌醇和非布司他治疗可显著降低体重、收缩压、血糖、胰岛素、血脂，并改善肾功能和内皮完整性。与别嘌醇相比，非布司他更能使血清空腹血糖、尿酸、过氧化氢酶和谷胱甘肽过氧化物酶活性正常化。
黄嘌呤氧化酶抑制剂改善了 MS 的影响。与别嘌醇相比，非布司他在降低血清空腹血糖、血脂、尿酸和抗氧化酶活性方面略占优势。
