解析tau蛋白的微管结合区域。
Untangling the tau microtubule-binding region.
作者信息
Toombs Jamie, Zetterberg Henrik
机构信息
Centre for Discovery Brain Sciences, UK Dementia Research Institute, The University of Edinburgh, UK.
UK Dementia Research Institute at UCL, London, UK.
出版信息
Brain. 2021 Mar 3;144(2):359-362. doi: 10.1093/brain/awaa468.
Abstract
This scientific commentary refers to ‘CSF tau microtubule binding region identifies tau tangle and clinical stages of Alzheimer’s disease’, by Horie (doi:10.1093/brain/awaa373).
摘要
本科学评论参考了堀江的《脑脊液tau微管结合区域可识别tau缠结及阿尔茨海默病的临床阶段》（doi:10.1093/brain/awaa373）。
相似文献
1
Untangling the tau microtubule-binding region.解析tau蛋白的微管结合区域。
Brain. 2021 Mar 3;144(2):359-362. doi: 10.1093/brain/awaa468.
2
Measuring Tau-microtubule affinity through cosedimentation assays.通过共沉降分析测定tau蛋白与微管的亲和力。
Methods Cell Biol. 2017;141:115-134. doi: 10.1016/bs.mcb.2017.06.015.
3
Tau repeat regions contain conserved histidine residues that modulate microtubule-binding in response to changes in pH.重复区域含有保守的组氨酸残基，这些残基可以调节微管结合，以响应 pH 值的变化。
J Biol Chem. 2019 May 31;294(22):8779-8790. doi: 10.1074/jbc.RA118.007004. Epub 2019 Apr 16.
4
The Microtubule-Associated Protein Tau Mediates the Organization of Microtubules and Their Dynamic Exploration of Actin-Rich Lamellipodia and Filopodia of Cortical Growth Cones.微管相关蛋白 Tau 介导微管的组织及其在皮质生长锥的富含肌动蛋白的片状伪足和丝状伪足中的动态探索。
J Neurosci. 2018 Jan 10;38(2):291-307. doi: 10.1523/JNEUROSCI.2281-17.2017. Epub 2017 Nov 22.
5
Studying Tau-Microtubule Interaction Using Single-Molecule TIRF Microscopy.使用单分子 TIRF 显微镜研究 Tau-微管相互作用。
Methods Mol Biol. 2020;2101:77-91. doi: 10.1007/978-1-0716-0219-5_6.
6
Local Nucleation of Microtubule Bundles through Tubulin Concentration into a Condensed Tau Phase.局部微管束的成核通过微管蛋白浓度凝聚到tau 相中。
Cell Rep. 2017 Sep 5;20(10):2304-2312. doi: 10.1016/j.celrep.2017.08.042.
7
Multivalent cross-linking of actin filaments and microtubules through the microtubule-associated protein Tau.通过微管相关蛋白 Tau 将肌动蛋白丝和微管进行多价交联。
Nat Commun. 2017 Dec 7;8(1):1981. doi: 10.1038/s41467-017-02230-8.
8
Tau stabilizes microtubules by binding at the interface between tubulin heterodimers.tau蛋白通过结合在微管蛋白异二聚体之间的界面来稳定微管。
Proc Natl Acad Sci U S A. 2015 Jun 16;112(24):7501-6. doi: 10.1073/pnas.1504081112. Epub 2015 Jun 1.
9
Evidence for two distinct binding sites for tau on microtubules.微管上tau蛋白存在两个不同结合位点的证据。
Proc Natl Acad Sci U S A. 2004 Apr 27;101(17):6746-51. doi: 10.1073/pnas.0400992101. Epub 2004 Apr 19.
10
Systematic identification of tubulin-interacting fragments of the microtubule-associated protein Tau leads to a highly efficient promoter of microtubule assembly.系统鉴定微管相关蛋白 Tau 的微管相互作用片段可高效促进微管组装。
J Biol Chem. 2011 Sep 23;286(38):33358-68. doi: 10.1074/jbc.M111.223545. Epub 2011 Jul 12.
引用本文的文献
1
Synaptotoxic effects of extracellular tau are mediated by its microtubule-binding region.细胞外tau蛋白的突触毒性作用由其微管结合区域介导。
Acta Neuropathol. 2025 Jun 2;149(1):56. doi: 10.1007/s00401-025-02897-0.
2
Stilbenes Against Alzheimer's Disease: A Comprehensive Review of Preclinical Studies of Natural and Synthetic Compounds Combined with the Contributions of Developed Nanodrug Delivery Systems.芪类化合物抗阿尔茨海默病：天然及合成化合物临床前研究综述以及新型纳米药物递送系统的贡献
Molecules. 2025 Apr 29;30(9):1982. doi: 10.3390/molecules30091982.
3
Large-scale deep proteomic analysis in Alzheimer's disease brain regions across race and ethnicity.跨种族和族裔的阿尔茨海默病脑区大规模深度蛋白质组学分析。
Alzheimers Dement. 2024 Dec;20(12):8878-8897. doi: 10.1002/alz.14360. Epub 2024 Nov 13.
4
Large-scale Deep Proteomic Analysis in Alzheimer's Disease Brain Regions Across Race and Ethnicity.跨种族和民族的阿尔茨海默病脑区大规模深度蛋白质组学分析
bioRxiv. 2024 Apr 26:2024.04.22.590547. doi: 10.1101/2024.04.22.590547.
5
Proteomic clusters underlie heterogeneity in preclinical Alzheimer's disease progression.蛋白质组簇是临床前阿尔茨海默病进展异质性的基础。
Brain. 2023 Jul 3;146(7):2944-2956. doi: 10.1093/brain/awac484.
6
Therapeutic Approach to Alzheimer's Disease: Current Treatments and New Perspectives.阿尔茨海默病的治疗方法：当前治疗手段与新视角
Pharmaceutics. 2022 May 24;14(6):1117. doi: 10.3390/pharmaceutics14061117.
本文引用的文献
1
CSF tau microtubule binding region identifies tau tangle and clinical stages of Alzheimer's disease.脑脊液 tau 微管结合区可识别 tau 缠结和阿尔茨海默病的临床阶段。
Brain. 2021 Mar 3;144(2):515-527. doi: 10.1093/brain/awaa373.
2
Blood Biomarkers: Democratizing Alzheimer's Diagnostics.血液生物标志物：使阿尔茨海默病诊断民主化。
Neuron. 2020 Jun 17;106(6):881-883. doi: 10.1016/j.neuron.2020.06.004.
3
Plasma P-tau181 in Alzheimer's disease: relationship to other biomarkers, differential diagnosis, neuropathology and longitudinal progression to Alzheimer's dementia.阿尔茨海默病患者血浆 P-tau181：与其他生物标志物的关系、鉴别诊断、神经病理学和向阿尔茨海默病痴呆的纵向进展。
Nat Med. 2020 Mar;26(3):379-386. doi: 10.1038/s41591-020-0755-1. Epub 2020 Mar 2.
4
Association of Longitudinal Changes in Cerebrospinal Fluid Total Tau and Phosphorylated Tau 181 and Brain Atrophy With Disease Progression in Patients With Alzheimer Disease.阿尔茨海默病患者脑脊液总 tau 和磷酸化 tau181 的纵向变化与脑萎缩与疾病进展的相关性。
JAMA Netw Open. 2019 Dec 2;2(12):e1917126. doi: 10.1001/jamanetworkopen.2019.17126.
5
Tau Phosphorylation Rates Measured by Mass Spectrometry Differ in the Intracellular Brain vs. Extracellular Cerebrospinal Fluid Compartments and Are Differentially Affected by Alzheimer's Disease.通过质谱法测量的tau蛋白磷酸化率在细胞内脑区与细胞外脑脊液区室中存在差异，并且受阿尔茨海默病的影响也不同。
Front Aging Neurosci. 2019 May 21;11:121. doi: 10.3389/fnagi.2019.00121. eCollection 2019.
6
Tau Proteolysis in the Pathogenesis of Tauopathies: Neurotoxic Fragments and Novel Biomarkers.tau 蛋白水解在 tau 病发病机制中的作用：神经毒性片段和新型生物标志物。
J Alzheimers Dis. 2018;63(1):13-33. doi: 10.3233/JAD-170959.
7
Tau Kinetics in Neurons and the Human Central Nervous System.神经元和人中枢神经系统中的 Tau 动力学。
Neuron. 2018 Mar 21;97(6):1284-1298.e7. doi: 10.1016/j.neuron.2018.02.015.
8
F-AV-1451 and CSF T-tau and P-tau as biomarkers in Alzheimer's disease.F-AV-1451 与脑脊液 T 蛋白和 P 蛋白作为阿尔茨海默病的生物标志物。
EMBO Mol Med. 2017 Sep;9(9):1212-1223. doi: 10.15252/emmm.201707809.
9
Identification of structural determinants on tau protein essential for its pathological function: novel therapeutic target for tau immunotherapy in Alzheimer's disease.确定tau蛋白对其病理功能至关重要的结构决定因素：阿尔茨海默病中tau免疫疗法的新型治疗靶点。
Alzheimers Res Ther. 2014 Aug 1;6(4):45. doi: 10.1186/alzrt277. eCollection 2014.
10
Distinct tau prion strains propagate in cells and mice and define different tauopathies.不同的 tau 朊病毒株在细胞和小鼠中传播，并定义了不同的 tau 病。
Neuron. 2014 Jun 18;82(6):1271-88. doi: 10.1016/j.neuron.2014.04.047. Epub 2014 May 22.
Zotero 插件