Universidade Estadual de Campinas, Campinas, SP, Brazil.
Washington University School of Medicine, St. Louis, MO, United States of America.
Rev Bras Ginecol Obstet. 2021 May;43(5):377-383. doi: 10.1055/s-0041-1729146. Epub 2021 Jun 28.
The coronavirus disease 2019 (COVID-19) is a pandemic viral disease, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The impact of the disease among the obstetric population remains unclear, and the study of the placenta can provide valuable information. Adequate sampling of the placental tissue can help characterize the pathways of viral infections.
A protocol of placental sampling is proposed, aiming at guaranteeing representativity of the placenta and describing the adequate conservation of samples and their integrity for future analysis. The protocol is presented in its complete and simplified versions, allowing its implementation in different complexity settings.
Sampling with the minimum possible interval from childbirth is the key for adequate sampling and storage. This protocol has already been implemented during the Zika virus outbreak.
A protocol for adequate sampling and storage of placental tissue is fundamental for adequate evaluation of viral infections on the placenta. During the COVID-19 pandemic, implementation of this protocol may help to elucidate critical aspects of the SARS-CoV-2 infection.
2019 年冠状病毒病（COVID-19）是一种由严重急性呼吸系统综合征冠状病毒 2（SARS-CoV-2）引起的大流行病毒性疾病。该疾病对产科人群的影响尚不清楚，而胎盘的研究可以提供有价值的信息。充分采集胎盘组织有助于描述病毒感染的途径。
提出了一种胎盘采样方案，旨在保证胎盘的代表性，并描述适当保存样本及其完整性，以便将来进行分析。该方案有完整和简化两个版本，允许在不同复杂程度的情况下实施。
分娩后尽可能短的时间间隔进行采样是充分采样和储存的关键。该方案已经在寨卡病毒爆发期间实施。
充分采集和储存胎盘组织的方案对于充分评估病毒对胎盘的感染至关重要。在 COVID-19 大流行期间，实施该方案可能有助于阐明 SARS-CoV-2 感染的关键方面。
