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Design and Development of the First Peptide-Chelating Bisphosphane Bioconjugate from a Novel Functionalized Phosphorus(III) Hydride Synthon.

作者信息

Gali Hariprasad, Karra Srinivasa R, Reddy V Sreenivasa, Katti Kattesh V

机构信息

Department of Radiology, Center for Radiological Research, Allton Building Laboratories, Room 106, University of Missouri-Columbia, Columbia, MO 65211 (USA), Fax: (+1) 573-884-5679.

出版信息

Angew Chem Int Ed Engl. 1999 Jul 12;38(13-14):2020-2023. doi: 10.1002/(SICI)1521-3773(19990712)38:13/14<2020::AID-ANIE2020>3.0.CO;2-R.

DOI:10.1002/(SICI)1521-3773(19990712)38:13/14<2020::AID-ANIE2020>3.0.CO;2-R
PMID:34182714
Abstract

Remarkable oxidative stability is shown by the carboxylate-functionalized primary bisphosphane 1. Compound 1 can be used in conjugation reactions with biomolecules for functionalization through the COOH group without prior protection of PH groups. A novel water-soluble bisphosphane was obtained by reaction of the PH groups of 1 with formaldehyde under mild conditions.

摘要

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