Children's Medical Research Institute, University of Sydney, Westmead, New South Wales, 2145, Australia.
Children's Medical Research Institute, University of Sydney, Westmead, New South Wales, 2145, Australia.
Trends Cell Biol. 2021 Oct;31(10):843-855. doi: 10.1016/j.tcb.2021.06.002. Epub 2021 Jun 26.
The nucleus is a dynamic environment containing chromatin, membraneless organelles, and specialized molecular structures at the nuclear membrane. Within the spectrum of DNA repair activities are observations of increased mobility of damaged chromatin and the displacement of DNA lesions to specific nuclear environments. Here, we focus on the role that nuclear-specific filamentous actin plays in mobilizing damaged chromatin in response to DNA double-strand breaks and replication stress. We also examine nuclear pore complexes and promyelocytic leukemia-nuclear bodies as specialized platforms for homology-directed repair. The literature suggests an emerging model where specific types of DNA lesions are subjected to nuclear-derived forces that mobilize damaged chromatin and promote interaction with repair hubs to facilitate specialized repair reactions.
核是一个动态的环境，包含染色质、无膜细胞器和核膜上的专门分子结构。在 DNA 修复活动的范围内，人们观察到受损染色质的流动性增加，以及 DNA 损伤转移到特定的核环境。在这里，我们专注于核特异性丝状肌动蛋白在响应 DNA 双链断裂和复制应激时动员受损染色质的作用。我们还研究了核孔复合物和早幼粒细胞白血病核体作为同源定向修复的专门平台。文献表明，一种新兴的模型正在出现，其中特定类型的 DNA 损伤受到源自核的力的影响，这些力动员受损的染色质，并促进与修复中心的相互作用，以促进专门的修复反应。
