Schmutz M, Klebs K, Baltzer V
Biology Research Laboratories, Ciba-Geigy Ltd, Basle, Switzerland.
J Neural Transm. 1988;72(3):245-57. doi: 10.1007/BF01243423.
The influence of antiepileptics on the evolution of rat amygdaloid kindling was studied. Under placebo conditions clonic convulsions and a spike-wave EEG pattern developed. Diazepam, clonazepam, clobazam and phenobarbital were most effective in suppressing the evolution of kindling; the effects of valproate sodium, ethosuximide and acetazolamide were somewhat less pronounced in this respect. Carbamazepine, oxcarbazepine and phenytoin, on the other hand, enhanced kindling development, i.e. the increase in duration of after-discharge was faster than in the placebo group. The results indicate that under the above experimental conditions drugs with no anti-absence component can be distinguished from those with an anti-absence component. The mechanism of action underlying the observed effects is not yet known; the hypothesis that under special conditions protective inhibitory neuronal activity can develop to absence type seizures is proposed.
研究了抗癫痫药物对大鼠杏仁核点燃发展过程的影响。在使用安慰剂的情况下，出现了阵挛性惊厥和棘慢波脑电图模式。地西泮、氯硝西泮、氯巴占和苯巴比妥在抑制点燃发展方面最为有效；在这方面，丙戊酸钠、乙琥胺和乙酰唑胺的效果稍弱。另一方面，卡马西平、奥卡西平和苯妥英钠则促进了点燃的发展，即后放电持续时间的增加比安慰剂组更快。结果表明，在上述实验条件下，可以区分出没有抗失神成分的药物和有抗失神成分的药物。观察到的这些效应背后的作用机制尚不清楚；有人提出了这样的假说，即在特殊条件下，保护性抑制性神经元活动可能发展为失神型癫痫发作。
