骨髓增殖性肿瘤中的血栓形成：病理生理学的最新进展。
Thrombosis in myeloproliferative neoplasms: update in pathophysiology.
机构信息
Hematology Division, Department of Medicine, Blood Research Center, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
Hematology Division, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
出版信息
Curr Opin Hematol. 2021 Sep 1;28(5):285-291. doi: 10.1097/MOH.0000000000000664.
PURPOSE OF REVIEW
This review summarizes high-impact research in myeloproliferative neoplasms (MPN) from the last 18 months, with a particular focus on basic science findings.
RECENT FINDINGS
A pseudo-hypoxia state with stabilization of hypoxia-inducible factor (HIFα exists that is central to cell growth, cell renewal, inflammation, and thrombotic potential in MPN hematopoietic cells.
SUMMARY
HIFα and inflammatory pathways are new therapeutic targets in MPN, with the potential to ameliorate thrombotic risk and perhaps eradicate mutant progenitor cells.
目的综述
本文总结了过去 18 个月中骨髓增殖性肿瘤（MPN）领域的重要研究进展，重点关注基础科学发现。
最近的发现
MPN 造血细胞中存在一种与细胞生长、细胞更新、炎症和血栓形成潜能密切相关的假缺氧状态，其特征为缺氧诱导因子（HIFα）的稳定。
总结
HIFα 和炎症通路是 MPN 的新治疗靶点，有可能降低血栓风险，并可能根除突变祖细胞。
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