Lee Myung-Won, Koh Jeong Suk, Kang Sora, Ryu Hyewon, Song Ik-Chan, Lee Hyo-Jin, Yun Hwan-Jung, Kim Seon Young, Kim Seong Soo, Jo Deog-Yeon
Division of Hematology/Oncology, Department of Internal Medicine, Chungnam National University College of Medicine, Daejeon, Korea.
Department of Laboratory Medicine, Chungnam National University College of Medicine, Daejeon, Korea.
Blood Res. 2023 Dec 31;58(4):173-180. doi: 10.5045/br.2023.2023125. Epub 2023 Oct 19.
Although atherosclerosis is likely to be involved in the development of arterial thrombotic events in patients with essential thrombocythemia (ET), abdominal aortic calcification (AAC) has rarely been investigated. We evaluated the prevalence and clinical relevance of AAC at the time of ET diagnosis.
This retrospective study included patients newly diagnosed with ET who underwent abdominal computed tomography (CT) at the time of diagnosis between January 2002 and December 2021 at Chungnam National University Hospital, Daejeon, Korea. CT images were reviewed and an aortic calcification score was assigned.
Of the 94 patients (median age, 62 yr; range, 18‒90 yr), AAC was detected in 62 (66.0%). AAC was most commonly mild (33.0%), followed by moderate (22.7%) and severe (5.3%). Old age [odds ratio (OR), 34.37; 95% confidence interval (CI), 12.32‒95.91; ＜0.001] was an independent risk factor for AAC. The patients with AAC had a higher WBC count (11.8±4.7 vs. 9.7±2.9×10/L, =0.017), higher neutrophil-to-lymphocyte ratio (4.3±2.7 vs. 3.1±1.5, =0.039), and higher V617F positivity (81.5% vs. 58.8%, =0.020) compared to those without AAC. AAC was an independent risk factor for arterial thrombotic vascular events that occurred before or at diagnosis of ET (OR, 4.12; 95% CI, 1.11‒15.85; =0.034).
AAC is common in patients with ET and is associated with arterial thrombotic events.
尽管动脉粥样硬化可能参与原发性血小板增多症（ET）患者动脉血栓形成事件的发生，但腹主动脉钙化（AAC）很少被研究。我们评估了ET诊断时AAC的患病率及其临床相关性。
这项回顾性研究纳入了2002年1月至2021年12月在韩国大田忠南国立大学医院诊断为ET时接受腹部计算机断层扫描（CT）的新诊断患者。对CT图像进行回顾并指定主动脉钙化评分。
94例患者（中位年龄62岁；范围18 - 90岁）中，62例（66.0%）检测到AAC。AAC最常见为轻度（33.0%），其次是中度（22.7%）和重度（5.3%）。高龄[比值比（OR），34.37；95%置信区间（CI），12.32 - 95.91；＜0.001]是AAC的独立危险因素。与无AAC的患者相比，有AAC的患者白细胞计数更高（11.8±4.7对9.7±2.9×10⁹/L，P = 0.017），中性粒细胞与淋巴细胞比值更高（4.3±2.7对3.1±1.5，P = 0.039），V617F阳性率更高（81.5%对58.8%，P = 0.020）。AAC是ET诊断前或诊断时发生的动脉血栓性血管事件的独立危险因素（OR，4.12；95% CI，1.11 - 15.85；P = 0.034）。
AAC在ET患者中很常见，且与动脉血栓形成事件相关。
