Department of Otolaryngology-Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing, China.
Key Laboratory of Otorhinolaryngology Head and Neck Surgery, Ministry of Education, Beijing Institute of Otorhinolaryngology, Beijing, China.
Laryngoscope. 2021 Sep;131(9):E2609-E2617. doi: 10.1002/lary.29678. Epub 2021 Jun 29.
OBJECTIVE/HYPOTHESIS: To examine the clinical features of benign intratracheal thyroid (ITT) and their management strategies and outcomes.
Case series study.
This systemic review was conducted in two international academic centers. This review includes 43 patients: one new case from the Massachusetts Eye and Ear Infirmary, four new cases from Beijing Tongren Hospital, and 38 previously published cases. We analyzed these 43 cases and summarized the patients' epidemiological data, clinical features, and treatment regimens.
ITTs were less common in men than in women (male:female ratio of 3:10). ITT was observed in patients as young as neonates and as old as 85 years. Orthotopic thyroid nodules were present in 55.8% of the patients with ITT. Malignancy was incidentally found in 4.6% of all ITTs. Imaging examinations showed that the ITTs were typically attached to the posterolateral/lateral tracheal wall of the first, second, or third tracheal rings. Tissue attachment between the ITT and normal thyroid lobes was seen in 59.5% of the patients. Thirty-seven patients underwent surgery: 30 underwent open surgery, and seven underwent endoscopic debulking resections. One neonate received thyroid suppression therapy. One patient with ITT and papillary thyroid cancer was treated with radiotherapy and ultimately died after recurrence.
Surgical resection is an effective treatment for benign ITT. We hypothesized that abnormalities during the embryonic development of Berry's ligament might play a role in ITT pathogenesis.
NA Laryngoscope, 131:E2609-E2617, 2021.
目的/假设：研究良性气管内甲状腺（ITT）的临床特征及其治疗策略和结局。
病例系列研究。
本系统评价在两个国际学术中心进行。本综述包括 43 例患者：来自马萨诸塞州眼耳医院的 1 例新病例，来自北京同仁医院的 4 例新病例，以及 38 例先前发表的病例。我们分析了这 43 例病例，并总结了患者的流行病学数据、临床特征和治疗方案。
男性患者中 ITT 比女性患者少见（男：女比例为 3:10）。ITT 可见于从新生儿到 85 岁的患者。55.8%的 ITT 患者存在甲状腺原位结节。所有 ITT 中偶然发现恶性肿瘤的比例为 4.6%。影像学检查显示，ITT 通常附着于第一、第二或第三气管环的后外侧/外侧气管壁。在 59.5%的患者中，可见 ITT 与正常甲状腺叶之间的组织附着。37 例患者接受了手术治疗：30 例接受了开放性手术，7 例接受了内镜下大块切除术。1 例新生儿接受了甲状腺抑制治疗。1 例 ITT 合并甲状腺乳头状癌的患者接受了放疗，最终因复发而死亡。
手术切除是治疗良性 ITT 的有效方法。我们假设 Berry 韧带在胚胎发育过程中的异常可能在 ITT 的发病机制中起作用。
无。喉镜，131：E2609-E2617，2021。
