Cellular and Molecular Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Iran.
Department of Pathology, Shahrekord University of Medical Sciences, Shahrekord, Iran.
Cell Biol Int. 2021 Oct;45(10):2086-2095. doi: 10.1002/cbin.11651. Epub 2021 Jun 29.
Prostate cancer (PCa) is one of the most epidemic types of cancer in men. The tumor microenvironment (TME) of PCa is involved in the emergence of immunosuppressive factors such as myeloid-derived suppressor cells (MDSC), which regulate the immune system by several mechanisms, including interleukin (IL)-10 production. On the other hand, IL-17 helper T cells (Th17) induce MDSCs and chronic inflammation in TME by producing IL-17. This study demonstrated that the frequency of CD33 pSTAT3 MDSC and IL-17 lymphocyte as well as IL-10 messenger RNA (mRNA) expression were significantly higher in the PCa patients than in the benign prostatic hyperplasia (BPH) group. Moreover, there was no significant relationship between the frequency of CD33 pSTAT3 MDSC, and IL-17 lymphocyte with Gleason scores in the PCa group. We suggested that the higher frequency of CD33 pSTAT3 MDSC and IL-17 lymphocyte and the more frequent expression of IL-10 mRNA in PCa patients may play roles in tumor progression from BPH to PCa.
前列腺癌 (PCa) 是男性中最常见的癌症类型之一。PCa 的肿瘤微环境 (TME) 涉及免疫抑制因子的出现，如髓系来源的抑制细胞 (MDSC)，它们通过多种机制调节免疫系统，包括白细胞介素 (IL)-10 的产生。另一方面，IL-17 辅助 T 细胞 (Th17) 通过产生 IL-17 在 TME 中诱导 MDSC 和慢性炎症。本研究表明，与良性前列腺增生 (BPH) 组相比，PCa 患者的 CD33 pSTAT3 MDSC 和 IL-17 淋巴细胞以及白细胞介素-10 信使 RNA (mRNA) 表达的频率明显更高。此外，在 PCa 组中，CD33 pSTAT3 MDSC 和 IL-17 淋巴细胞的频率与 Gleason 评分之间没有显著关系。我们认为，PCa 患者中 CD33 pSTAT3 MDSC 和 IL-17 淋巴细胞的较高频率以及 IL-10 mRNA 的更频繁表达可能在从 BPH 到 PCa 的肿瘤进展中发挥作用。
