小儿年龄组中与Vogt-小柳-原田病相关的葡萄膜炎的长期预后
Long-term Outcomes of Uveitis Associated with Vogt-Koyanagi-Harada Disease in the Pediatric Age Group.
作者信息
AlBloushi Abdulrahman F, AlEnezi Saad H, Al Owaifeer Adi Mohammed, Al-Hadlaq Omar S, Gikandi Priscilla W, Abu El-Asrar Ahmed M
机构信息
Department of Ophthalmology, College of Medicine, King Saud University, Riyadh, Saudi Arabia.
Ophthalmology Department, College of Medicine, Majmaah University, Al Majma'ah, Saudi Arabia.
出版信息
Ocul Immunol Inflamm. 2022 Oct-Nov;30(7-8):1669-1677. doi: 10.1080/09273948.2021.1933074. Epub 2021 Jun 29.
PURPOSE
To investigate the outcomes of uveitis associated with Vogt-Koyanagi-Harada (VKH) disease in pediatric age group (aged 16 years and under).
METHODS
A retrospective review of patients with VKH disease.
RESULTS
Among the 244 patients identified, 38 (76 eyes) were children. Among them, five had insulin-dependent diabetes mellitus. 21 presented with initial-onset acute disease and 17 with chronic recurrent disease. The mean follow-up period was 59.1 months. At presentation, chronic recurrent disease was associated with more severe inflammation as indicated by the presence of mutton-fat keratic precipitates ( < .001), iris nodules ( = .005) and posterior synechiae ( < .001). During follow-up, the rate of complications was higher in children with chronic recurrent disease compared with initial-onset acute disease ( < .001). 92.4% of the eyes with initial-onset acute disease achieved a final visual acuity of ≥20/40 compared with 70.6% of the eyes with chronic recurrent disease ( = .013).
CONCLUSIONS
Chronic recurrent VKH disease in children is associated with worse outcomes.
目的
研究小儿年龄组（16岁及以下）与葡萄膜大脑炎（VKH）相关的葡萄膜炎的治疗结果。
方法
对VKH疾病患者进行回顾性研究。
结果
在确定的244例患者中，38例（76只眼）为儿童。其中，5例患有胰岛素依赖型糖尿病。21例表现为初发性急性疾病，17例表现为慢性复发性疾病。平均随访期为59.1个月。就诊时，慢性复发性疾病与更严重的炎症相关，表现为羊脂状角膜后沉着物（<.001）、虹膜结节（=.005）和虹膜后粘连（<.001）。随访期间，慢性复发性疾病患儿的并发症发生率高于初发性急性疾病患儿（<.001）。初发性急性疾病患儿92.4%的患眼最终视力达到≥20/40，而慢性复发性疾病患儿患眼的这一比例为70.6%（=.013）。
结论
儿童慢性复发性VKH疾病的治疗结果较差。
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