Micek Hannah M, Visetsouk Mike R, Fleszar Andrew J, Kreeger Pamela K
Department of Biomedical Engineering, University of Wisconsin-Madison, Madison, WI, USA.
University of Wisconsin Carbone Cancer Center, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
Adv Exp Med Biol. 2020;1296:199-213. doi: 10.1007/978-3-030-59038-3_12.
High-grade serous ovarian cancer (HGSOC) is the most common and deadly subtype of ovarian cancer as it is commonly diagnosed after substantial metastasis has already occurred. The past two decades have been an active era in HGSOC research, with new information on the origin and genomic signature of the tumor cell. Additionally, studies have begun to characterize changes in the HGSOC microenvironment and examine the impact of these changes on tumor progression and response to therapies. While this knowledge may provide valuable insight into better prognosis and treatments for HGSOCs, its collection, synthesis, and application are complicated by the number of unique microenvironments in the disease-the initiating site (fallopian tube), first metastasis (ovary), distal metastases (peritoneum), and recurrent/platinum-resistant setting. Here, we review the state of our understanding of these diverse sites and highlight remaining questions.
高级别浆液性卵巢癌（HGSOC）是卵巢癌最常见且致命的亚型，因为它通常在已经发生大量转移后才被诊断出来。在过去的二十年里，HGSOC研究处于活跃阶段，有了关于肿瘤细胞起源和基因组特征的新信息。此外，研究已经开始描述HGSOC微环境的变化，并研究这些变化对肿瘤进展和治疗反应的影响。虽然这些知识可能为改善HGSOC的预后和治疗提供有价值的见解，但其收集、综合和应用因该疾病中独特微环境的数量而变得复杂——起始部位（输卵管）、首次转移部位（卵巢）、远处转移部位（腹膜）以及复发/铂耐药情况。在这里，我们回顾了我们对这些不同部位的理解现状，并突出了尚存的问题。
