School of Pharmaceutical and Materials Engineering, Taizhou University, Taizhou 318000, P. R. China.
Institute of Advanced Studies, Taizhou University, Taizhou 318000, P. R. China.
J Org Chem. 2021 Jul 16;86(14):9289-9298. doi: 10.1021/acs.joc.1c00171. Epub 2021 Jun 29.
A transition metal-free method for de novo construction of diverse sulfonated pyrazoles from readily available sulfonyl hydrazides, 1,3-diketones, and sodium sulfinates was established under mild conditions. Pyrazoles bearing two different sulfonyl groups were obtained in one step. The method features a diversity of substituents of the pyrazole products and a remarkably simple work-up.
建立了一种在温和条件下，从易得的磺酰基腙、1,3-二酮和亚硫酸钠出发，用于新型构建各种磺化吡唑的无过渡金属方法。该方法可一步得到含两个不同磺酰基的吡唑产物。该方法具有吡唑产物的多种取代基和显著简单的后处理的特点。
