室温条件下无过渡金属条件下从磺酰肼、1,3-二酮和磺酸钠出发的磺化吡唑的全新合成方法。
Transition Metal-Free De Novo Synthesis of Sulfonated Pyrazoles from Sulfonyl Hydrazides, 1,3-Diketones, and Sodium Sulfinates at Room Temperature.
机构信息
School of Pharmaceutical and Materials Engineering, Taizhou University, Taizhou 318000, P. R. China.
Institute of Advanced Studies, Taizhou University, Taizhou 318000, P. R. China.
出版信息
J Org Chem. 2021 Jul 16;86(14):9289-9298. doi: 10.1021/acs.joc.1c00171. Epub 2021 Jun 29.
A transition metal-free method for de novo construction of diverse sulfonated pyrazoles from readily available sulfonyl hydrazides, 1,3-diketones, and sodium sulfinates was established under mild conditions. Pyrazoles bearing two different sulfonyl groups were obtained in one step. The method features a diversity of substituents of the pyrazole products and a remarkably simple work-up.
建立了一种在温和条件下，从易得的磺酰基腙、1,3-二酮和亚硫酸钠出发，用于新型构建各种磺化吡唑的无过渡金属方法。该方法可一步得到含两个不同磺酰基的吡唑产物。该方法具有吡唑产物的多种取代基和显著简单的后处理的特点。
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