Sukenik S, Henkin J, Zimlichman S, Skibin A, Neuman L, Pras M, Horowitz J, Shainkin-Kestenbaum R
Rheumatology Unit, Soroka Medical Center, Tel-Aviv, Israel.
J Rheumatol. 1988 Jun;15(6):942-5.
Serum and synovial fluid (SF) levels of serum amyloid A (SAA) and C-reactive protein (CRP) were measured in 46 cases of various inflammatory arthritis (Group 1), and in 40 cases of noninflammatory arthritis: 18 cases of osteoarthritis (Group 2) and 22 cases of traumatic arthritis (Group 3). Serum and SF SAA levels were markedly elevated in Group 1: 126.4 micrograms/ml +/- 19.2 SEM and 46.4 micrograms/ml +/- 10.5 SEM, respectively; moderately elevated in Group 2: 10.1 micrograms/ml +/- 2.9 SEM, 4.0 micrograms/ml +/- 1.1 SEM and moderately elevated in Group 3: 10.4 micrograms/ml +/- 1.2 SEM, 4.0 micrograms/ml +/- 1.2 SEM, respectively. Serum/SF SAA ratios were similar in all 3 groups and ranged between 2.52-2.72. In comparison to SAA, the increment of serum and SF CRP above normal levels was moderate. A positive strong correlation was found between serum SAA and serum CRP: r = 0.64 (p less than 0.001) and between SF SAA and SF CRP: r = 0.59 (p less than 0.0001). SF SAA did not correlate with the number of SF white blood cells but did correlate with the percent of SF polymorphonuclear cells: r = 0.23 (p less than 0.05).
对46例各种炎性关节炎患者（第1组）、40例非炎性关节炎患者进行了血清淀粉样蛋白A（SAA）和C反应蛋白（CRP）的血清及滑液（SF）水平检测。其中，40例非炎性关节炎患者包括18例骨关节炎患者（第2组）和22例创伤性关节炎患者（第3组）。第1组患者的血清及滑液SAA水平显著升高，分别为126.4微克/毫升±19.2标准误和46.4微克/毫升±10.5标准误；第2组患者的血清及滑液SAA水平中度升高，分别为10.1微克/毫升±2.9标准误和4.0微克/毫升±1.1标准误；第3组患者的血清及滑液SAA水平也中度升高，分别为10.4微克/毫升±1.2标准误和4.0微克/毫升±1.2标准误。三组患者的血清/滑液SAA比值相似，范围在2.52 - 2.72之间。与SAA相比，血清及滑液CRP高于正常水平的增幅适中。血清SAA与血清CRP之间呈强正相关：r = 0.64（p < 0.001），滑液SAA与滑液CRP之间也呈强正相关：r = 0.59（p < 0.0001）。滑液SAA与滑液白细胞数量无相关性，但与滑液多形核细胞百分比相关：r = 0.23（p < 0.05）。
