Christensen Michelle B, Langhorn Rebecca, Goddard Amelia, Andreasen Eva B, Moldal Elena, Tvarijonaviciute Asta, Kirpensteijn Jolle, Jakobsen Sabrina, Persson Frida, Kjelgaard-Hansen Mads
Department of Veterinary Clinical and Animal Sciences, University of Copenhagen, Groennegaardsvej 3 ground floor, Frederiksberg, Denmark (Christensen, Langhorn, Andreasen, Jacobsen, Persson, Kjelgaard-Hansen); Department of Companion Animal Clinical Studies, University of Pretoria, Private Bag X04, Onderstepoort, 0110, Pretoria, South Africa (Goddard); Department of Companion Animal Sciences, Norwegian School of Veterinary Science, P.O. Box 8146 Dep. N-0033 Oslo, Norway (Moldal); Department of Animal Medicine and Surgery, the Veterinary Faculty, Campus de Espinardo, University of Murcia, 30100 Murcia, Spain (Tvarijonaviciute); and Department of Clinical Sciences of Companion Animals, Faculty of Veterinary Medicine, University of Utrecht, Yalelaan 108, 3584 CM Utrecht, Netherlands (Kirpensteijn).
Can Vet J. 2014 Feb;55(2):161-8.
The diagnostic performance of canine serum amyloid A (SAA) was compared with that of C-reactive protein (CRP) in the detection of systemic inflammation in dogs. Sera from 500 dogs were retrospectively included in the study. C-reactive protein and SAA were measured using validated automated assays. The overlap performance, clinical decision limits, overall diagnostic performance, correlations, and agreement in the clinical classification between these 2 diagnostic markers were compared. Significantly higher concentrations of both proteins were detected in dogs with systemic inflammation (SAA range: 48.75 to > 2700 mg/L; CRP range: 0.4 to 907.4 mg/L) compared to dogs without systemic inflammation (SAA range: 1.06 to 56.4 mg/L; CRP range: 0.07 to 24.7 mg/L). Both proteins were shown to be sensitive and specific markers of systemic inflammation in dogs. Significant correlations and excellent diagnostic agreement were observed between the 2 markers. However, SAA showed a wider range of concentrations and a significantly superior overall diagnostic performance compared with CRP.
在检测犬类全身炎症方面，对犬血清淀粉样蛋白A（SAA）和C反应蛋白（CRP）的诊断性能进行了比较。本研究回顾性纳入了500只犬的血清。使用经过验证的自动化检测方法测定C反应蛋白和SAA。比较了这两种诊断标志物的重叠性能、临床决策限、总体诊断性能、相关性以及临床分类中的一致性。与无全身炎症的犬相比，全身炎症犬体内这两种蛋白的浓度均显著更高（SAA范围：48.75至>2700mg/L；CRP范围：0.4至907.4mg/L）（无全身炎症犬的SAA范围：1.06至56.4mg/L；CRP范围：0.07至24.7mg/L）。两种蛋白均被证明是犬全身炎症的敏感且特异的标志物。两种标志物之间观察到显著相关性和良好的诊断一致性。然而，与CRP相比，SAA显示出更宽的浓度范围和显著更优的总体诊断性能。
