犬血清淀粉样蛋白A和C反应蛋白作为全身炎症诊断标志物的比较。
Comparison of serum amyloid A and C-reactive protein as diagnostic markers of systemic inflammation in dogs.
作者信息
Christensen Michelle B, Langhorn Rebecca, Goddard Amelia, Andreasen Eva B, Moldal Elena, Tvarijonaviciute Asta, Kirpensteijn Jolle, Jakobsen Sabrina, Persson Frida, Kjelgaard-Hansen Mads
机构信息
Department of Veterinary Clinical and Animal Sciences, University of Copenhagen, Groennegaardsvej 3 ground floor, Frederiksberg, Denmark (Christensen, Langhorn, Andreasen, Jacobsen, Persson, Kjelgaard-Hansen); Department of Companion Animal Clinical Studies, University of Pretoria, Private Bag X04, Onderstepoort, 0110, Pretoria, South Africa (Goddard); Department of Companion Animal Sciences, Norwegian School of Veterinary Science, P.O. Box 8146 Dep. N-0033 Oslo, Norway (Moldal); Department of Animal Medicine and Surgery, the Veterinary Faculty, Campus de Espinardo, University of Murcia, 30100 Murcia, Spain (Tvarijonaviciute); and Department of Clinical Sciences of Companion Animals, Faculty of Veterinary Medicine, University of Utrecht, Yalelaan 108, 3584 CM Utrecht, Netherlands (Kirpensteijn).
出版信息
Can Vet J. 2014 Feb;55(2):161-8.
The diagnostic performance of canine serum amyloid A (SAA) was compared with that of C-reactive protein (CRP) in the detection of systemic inflammation in dogs. Sera from 500 dogs were retrospectively included in the study. C-reactive protein and SAA were measured using validated automated assays. The overlap performance, clinical decision limits, overall diagnostic performance, correlations, and agreement in the clinical classification between these 2 diagnostic markers were compared. Significantly higher concentrations of both proteins were detected in dogs with systemic inflammation (SAA range: 48.75 to > 2700 mg/L; CRP range: 0.4 to 907.4 mg/L) compared to dogs without systemic inflammation (SAA range: 1.06 to 56.4 mg/L; CRP range: 0.07 to 24.7 mg/L). Both proteins were shown to be sensitive and specific markers of systemic inflammation in dogs. Significant correlations and excellent diagnostic agreement were observed between the 2 markers. However, SAA showed a wider range of concentrations and a significantly superior overall diagnostic performance compared with CRP.
在检测犬类全身炎症方面，对犬血清淀粉样蛋白A（SAA）和C反应蛋白（CRP）的诊断性能进行了比较。本研究回顾性纳入了500只犬的血清。使用经过验证的自动化检测方法测定C反应蛋白和SAA。比较了这两种诊断标志物的重叠性能、临床决策限、总体诊断性能、相关性以及临床分类中的一致性。与无全身炎症的犬相比，全身炎症犬体内这两种蛋白的浓度均显著更高（SAA范围：48.75至>2700mg/L；CRP范围：0.4至907.4mg/L）（无全身炎症犬的SAA范围：1.06至56.4mg/L；CRP范围：0.07至24.7mg/L）。两种蛋白均被证明是犬全身炎症的敏感且特异的标志物。两种标志物之间观察到显著相关性和良好的诊断一致性。然而，与CRP相比，SAA显示出更宽的浓度范围和显著更优的总体诊断性能。
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