Sauder P, Livardjani F, Jaeger A, Kopferschmitt J, Heimburger R, Waller C, Mantz J M, Leroy M
Reanimation Medicale et Centre Anti-Poisons, Hopital Civil, Strasbourg, France.
J Toxicol Clin Toxicol. 1988;26(3-4):189-97. doi: 10.3109/15563658809000346.
A 27 year-old man developed after ingestion of mercury chloride, 6 g, a hypovolemic shock, an acute renal failure and a necrosis of the stomach which required a total gastrectomy. The anuria did not improve and required 42 hemodialyses. Subsequent evolution showed numerous complications and the patient died on the 91st day. On admission mercury plasma concentration was 5 mg/L and decreased slowly with an apparent half-life of 226 hours. Hemodialyses were ineffective for mercury elimination: mercury clearances varied between -10 and + 1.5 ml/min. Seventeen mg of mercury were removed by six plasma exchanges: the mercury clearance was mean 17.3 ml/min. Among the extracorporeal elimination methods, plasma exchange appears to be the most efficient for inorganic mercury and it could be usefull in association with chelation therapy at the early phase of the intoxication.
一名27岁男子在摄入6克氯化汞后，出现低血容量性休克、急性肾衰竭和胃坏死，需行全胃切除术。无尿症状未改善，需要进行42次血液透析。随后的病情发展显示出许多并发症，患者在第91天死亡。入院时血浆汞浓度为5毫克/升，并缓慢下降，表观半衰期为226小时。血液透析对汞的清除无效：汞清除率在-10至+1.5毫升/分钟之间变化。通过六次血浆置换清除了17毫克汞：汞清除率平均为17.3毫升/分钟。在体外清除方法中，血浆置换似乎是清除无机汞最有效的方法，在中毒早期与螯合疗法联合使用可能会有帮助。
