减重手术对内源性性激素和性激素结合球蛋白水平的影响：系统评价和荟萃分析。
Effect of bariatric surgery on endogenous sex hormones and sex hormone-binding globulin levels: a systematic review and meta-analysis.
机构信息
Department of Clinical Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran.
Pediatric Gastroenterology, Hepatology and Nutrition Research Center, Research Institute for Children's Health, Shahid Beheshti University of Medical Sciences, Tehran, Iran; Pediatric Gastroenterology, Hepatology and Nutrition Research Center, Research Institute for Children's Health, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
出版信息
Surg Obes Relat Dis. 2021 Sep;17(9):1621-1636. doi: 10.1016/j.soard.2021.05.003. Epub 2021 May 12.
BACKGROUND
Most studies have shown beneficial effect of bariatric surgery (BS) on serum levels of sex hormones.
OBJECTIVE
A systematic review and meta-analysis was conducted to examine the magnitude of possible changes in levels of sex hormones following BS.
SETTINGS
Electronic databases were searched, including PubMed, Scopus, Web of Science, and Embase, for relevant studies.
METHODS
The heterogeneity of the studies was examined by χ tests and the degree of heterogeneity was estimated using I statistic.
RESULTS
The results of pooled analyses revealed that BS caused a significant increase in luteinizing hormone (LH), follicular stimulating hormone (FSH), total testosterone (TT), and sex hormone binding globulin (SHBG) levels and conversely, decreased dehydroepiandrosterone (DHEA) and estradiol (E2) levels in males. For females, BS significantly increased LH, FSH, and SHBG levels and conversely, decreased androstenedione (AE), E2 and TT levels. Additionally, the level of progesterone (P), prolactin (PRL), free testosterone (FT) and dehydroepiandrosterone sulfate (DHEA-S) showed no significant changes in patients who had undergone BS.
CONCLUSION
BS changed most sex hormones levels including LH, FSH, TT, SHBG, AE, DHEA, and E2. It seems that BS is able to exert substantial impacts on sex hormones levels and as well as sexual function, however, larger, and more precise trials are required to specifically focus on these claims.
背景
大多数研究表明减重手术（BS）对性激素的血清水平有有益影响。
目的
进行系统评价和荟萃分析，以检查 BS 后性激素水平可能发生的变化幅度。
设置
检索电子数据库，包括 PubMed、Scopus、Web of Science 和 Embase，以获取相关研究。
方法
通过 χ 检验检查研究的异质性，并使用 I 统计量估计异质性程度。
结果
汇总分析的结果表明，BS 导致黄体生成素（LH）、卵泡刺激素（FSH）、总睾酮（TT）和性激素结合球蛋白（SHBG）水平显著升高，而脱氢表雄酮（DHEA）和雌二醇（E2）水平降低。对于女性，BS 显著增加 LH、FSH 和 SHBG 水平，而相反，降低雄烯二酮（AE）、E2 和 TT 水平。此外，接受 BS 的患者孕激素（P）、催乳素（PRL）、游离睾酮（FT）和脱氢表雄酮硫酸盐（DHEA-S）的水平没有明显变化。
结论
BS 改变了大多数性激素水平，包括 LH、FSH、TT、SHBG、AE、DHEA 和 E2。BS 似乎能够对性激素水平和性功能产生实质性影响，但需要更大、更精确的试验来专门关注这些说法。
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