Augustine Merline, Murugesan Mohandoss, Nayanar Sangeetha K, Padmanabhan Maya
Transfusion Medicine, Malabar Cancer Centre, Thalassery, Kerala, India.
Transfusion Medicine, Malabar Cancer Centre, Thalassery, Kerala, India.
Transfus Apher Sci. 2021 Oct;60(5):103198. doi: 10.1016/j.transci.2021.103198. Epub 2021 Jun 24.
This study aims to determine the phlebotomy and procedural outcomes using a vein assessment tool (VAT) in Double Dose Platelet (DDP) collections by apheresis.
VAT was based on assessing vein visibility, palpation and size with maximum score of 12 and the least being 0 and the scores were graded as adequate and inadequate. A vein-viewer was used for studying cubital vein patterns (type 1-5). Phlebotomy outcome was defined based on need for re-puncture. Procedural outcomes in terms of target yield attained and RBC reinfusion completed. Chi square test and Mann- Whitney U test were used to assess the vein score and pattern against phlebotomy and procedural outcome.
Out of 200 DDP collections, the phlebotomy was successful in 88 % with good procedural outcome in 94 % donations. The cut off in VAT scores for successful phlebotomy was ≥8 (AUC: 70 %). Median vein scores of the arm selected for phlebotomy was 9 and graded adequate in 154 (77 %) donations.Odds for successful phlebotomy was 3.7 times higher when donors had an adequate VAT grades(p = 0.003). Procedural outcomes was favourable when at least one arm had adequate VAT grade when compared to both arms being inadequate (98 % vs 82 %; p < 0.001). Phlebotomy failure was more with first time apheresis donors than repeat apheresis donors (p = 0.014).
This study indicated that a VAT score with a cut off of ≥8 had better phlebotomy and procedural outcomes in DDP collections and that donor with at least one arm having the VAT score of ≥8 are preferred for DDP collections.
本研究旨在确定在通过单采进行双剂量血小板(DDP)采集时,使用静脉评估工具(VAT)的静脉穿刺及操作结果。
VAT基于对静脉可见性、触诊和大小的评估,最高分为12分,最低分为0分,分数分为足够和不足。使用静脉观察仪研究肘正中静脉模式(1 - 5型)。静脉穿刺结果根据再次穿刺的需求来定义。操作结果依据获得的目标产量和完成的红细胞回输来确定。采用卡方检验和曼 - 惠特尼U检验来评估静脉分数和模式与静脉穿刺及操作结果之间的关系。
在200例DDP采集中,88%的静脉穿刺成功,94%的捐献获得了良好的操作结果。成功静脉穿刺的VAT分数临界值为≥8(曲线下面积:70%)。用于静脉穿刺的手臂的中位静脉分数为9分,154例(77%)捐献的分数被评为足够。当捐献者的VAT等级足够时,成功静脉穿刺的几率高3.7倍(p = 0.003)。与双臂等级均不足相比,当至少有一只手臂的VAT等级足够时,操作结果更有利(98%对82%;p < 0.001)。首次单采捐献者的静脉穿刺失败率高于重复单采捐献者(p = 0.014)。
本研究表明,在DDP采集中,临界值≥8的VAT分数具有更好的静脉穿刺及操作结果,并且对于DDP采集,优先选择至少有一只手臂的VAT分数≥8的捐献者。