昂丹司琼和托烷司琼预防术后恶心呕吐的比较：一项随机对照试验的荟萃分析。
Comparison of ondansetron and tropisetron in preventing postoperative nausea and vomiting: A meta-analysis of randomized controlled trials.
机构信息
From the Department of Computer Network (Wang R), Technology School, Jilin Business and Technology College, Changchun, Jilin; from the Department of Anesthesiology (Song, Chen, Wang N); and from the Department of Urology (Wang J), The First Hospital of Jilin University, Changchun, China.
出版信息
Saudi Med J. 2021 Jul;42(7):707-713. doi: 10.15537/smj.2021.42.7.20210135.
OBJECTIVES
To compare the efficacy of prophylactic ondansetron and tropisetron for postoperative nausea and vomiting (PONV).
METHODS
A literature search was performed to identify studies that compare the efficiency of ondansetron with that of tropisetron in preventing PONV. Only randomized controlled trials updated to January, 2021 were included.
RESULTS
The final pooled analysis included 14 studies totaling 1705 patients and indicated that ondansetron was 39% less effective than tropisetron in preventing postoperative vomiting with a higher incidence of dizziness. However, no significant difference was detected between ondansetron and tropisetron in PONV, postoperative nausea, antiemetic treatment, and headache.
CONCLUSIONS
Tropisetron is superior to ondansetron in preventing postoperative vomiting.PROSPERO No: CRD42021237368.
目的
比较昂丹司琼和托烷司琼预防术后恶心呕吐（PONV）的疗效。
方法
检索比较昂丹司琼与托烷司琼预防 PONV 效果的文献，纳入截止至 2021 年 1 月更新的随机对照试验。
结果
最终的汇总分析纳入 14 项研究共 1705 例患者，结果显示昂丹司琼预防术后呕吐的有效率比托烷司琼低 39%，且头晕的发生率更高。然而，在 PONV、术后恶心、止吐治疗和头痛方面，昂丹司琼与托烷司琼无显著差异。
结论
托烷司琼预防术后呕吐的疗效优于昂丹司琼。PROSPERO 注册号：CRD42021237368。
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