Discipline of Clinical Pharmacy, School of Pharmaceutical Sciences, Universiti Sains Malaysia, Penang, Malaysia.
Department of Pharmacy Practice, College of Clinical Pharmacy, Hodeidah University, Al Hodeidah, Yemen.
Pharmacogenet Genomics. 2021 Aug 1;31(6):125-132. doi: 10.1097/FPC.0000000000000430.
Pharmacogenetics (PGx) science has evolved significantly with a huge number of studies exploring the effect of genetic variants on interindividual variability of drug response. In this study, we assessed the knowledge, attitudes and preparedness of Pharm-D vs. medical students toward PGx.
A paper-based cross-sectional survey was performed. A pilot-tested questionnaire consisting of 21 questions (demographics 5, knowledge 6, attitude 6, and preparedness 4) was administered to 900 healthcare students at different years of study. Descriptive and inferential analyses were used.
Out of the 900 students approached, 852 (94.7%) completed the questionnaire. The overall students' mean (SD) percentage knowledge score (PKS) was poor [46.7% (18.7)]. The mean (SD) attitude and preparedness scores for all students were 4.68 (1.32), and 1.9 (1.40), respectively, indicating overall positive attitudes, but low preparedness to apply PGx to clinical care. Pharm-D students' overall PKS was significantly higher than medical students (P < 0.0001). However, there was no significant difference in terms of attitude and preparedness scores. Interestingly, as the year of study increased, the knowledge scores increased as well, with 6th-year students had the highest knowledge scores, while preparedness in applying PGx was higher among the junior students (the 3rd and 4th year of study).
Pharm-D and medical students have inadequate knowledge and low preparedness despite the overall positive attitude towards PGx. There is a need to raise knowledge and to enhance the level of preparedness of medical and Pharm-D students towards PGx and its applications in clinical practice.
药物遗传学（PGx）科学有了很大的发展，有大量的研究探索遗传变异对药物反应个体间差异的影响。在这项研究中，我们评估了药学博士与医学生对 PGx 的知识、态度和准备情况。
进行了基于纸质的横断面调查。向不同学习阶段的 900 名医学生发放了一份经过试点测试的问卷，共 21 个问题（人口统计学 5 个，知识 6 个，态度 6 个，准备情况 4 个）。采用描述性和推断性分析。
在接受调查的 900 名学生中，有 852 名（94.7%）完成了问卷。学生总体平均（SD）知识得分（PKS）较差[46.7%（18.7%）]。所有学生的平均（SD）态度和准备分数分别为 4.68（1.32）和 1.9（1.40），表明总体态度积极，但准备将 PGx 应用于临床护理的程度较低。药学博士学生的总体 PKS 明显高于医学学生（P<0.0001）。然而，在态度和准备分数方面没有显著差异。有趣的是，随着学习年限的增加，知识得分也随之增加，六年级学生的知识得分最高，而应用 PGx 的准备程度在低年级学生（三年级和四年级）中较高。
尽管对 PGx 总体持积极态度，但药学博士和医学学生的知识不足，准备程度低。需要提高医学生和药学博士对 PGx 及其在临床实践中的应用的知识水平和准备程度。
