Podder Indrashis, Agarwal Komal, Anurag Anubhav
Department of Dermatology, Venereology and Leprosy, College of Medicine and Sagore Dutta Hospital, West Bengal, India.
Department of Dermatology, Calcutta National Medical College, West Bengal, India.
Indian J Dermatol. 2021 Mar-Apr;66(2):223. doi: 10.4103/ijd.IJD_321_20.
Acne vulgaris is a chronic inflammatory disease primarily affecting the adolescents, with a profound impact on their quality of life. There is conflicting data regarding its association with metabolic syndrome.
To assess the prevalence of metabolic syndrome (MetS) and obesity in patients with acne vulgaris, and determine its impact on the patient's quality of life.
We conducted a cross-sectional, case-control study involving 50 patients with acne vulgaris (cases) and 50 age and sex-matched controls without acne. Acne vulgaris was graded according to clinical severity using the GAGS scale. NCEP-ATP III criteria and modified classification of body mass index (BMI) for Asian Indians were used to diagnose MetS and obesity, respectively, in both cases and controls. We used the DLQI questionnaire to evaluate its impact on the quality of life.
Cases and controls were comparable with respect to parameters like age, BMI, systolic blood pressure (SBP), diastolic blood pressure (DSBP), and serum triglyceride while fasting blood sugar (FBS, case > control) and serum high-density lipoprotein (HDL, control > case) were significantly different ( < 0.05, independent -test). Prevalence of MetS was higher in cases (32%) than controls (14%), though comparable ( = 0.06, Chi-square). Only SBP, FBS, and serum HDL showed a significant correlation with the severity of acne. Obesity was comparable between cases (18%) and controls (10%), without any relation to acne severity. Acne exerted a moderate impact on the quality of life (mean DLQI 9.3). Severe acne showed higher DLQI, although their correlation was not statistically significant ( = 0.8, ANOVA).
Although acne patients may develop MetS and obesity, there is a lack of significant association. Thus, we should examine all obese patients, irrespective of dermatological disorder, to rule out metabolic syndrome. Acne also affects the patient's quality of life, thus emphasizing the need for additional psychosocial counselling.
寻常痤疮是一种主要影响青少年的慢性炎症性疾病，对他们的生活质量有深远影响。关于其与代谢综合征的关联，数据存在矛盾。
评估寻常痤疮患者中代谢综合征（MetS）和肥胖的患病率，并确定其对患者生活质量的影响。
我们进行了一项横断面病例对照研究，纳入50例寻常痤疮患者（病例组）和50例年龄及性别匹配的无痤疮对照者。根据临床严重程度使用GAGS量表对寻常痤疮进行分级。分别采用美国国家胆固醇教育计划成人治疗组第三次报告（NCEP-ATP III）标准和针对亚洲印度人的改良体重指数（BMI）分类来诊断病例组和对照组中的MetS和肥胖。我们使用皮肤病生活质量指数（DLQI）问卷来评估其对生活质量的影响。
病例组和对照组在年龄、BMI、收缩压（SBP）、舒张压（DSBP）和血清甘油三酯等参数方面具有可比性，而空腹血糖（FBS，病例组>对照组）和血清高密度脂蛋白（HDL，对照组>病例组）存在显著差异（P<0.05，独立样本t检验）。病例组中MetS的患病率（32%）高于对照组（14%），尽管差异无统计学意义（P=0.06，卡方检验）。仅SBP、FBS和血清HDL与痤疮严重程度呈显著相关。病例组（18%）和对照组（10%）的肥胖情况具有可比性，且与痤疮严重程度无关。痤疮对生活质量有中度影响（平均DLQI为9.3）。重度痤疮的DLQI较高，尽管其相关性无统计学意义（P=0.8，方差分析）。
尽管痤疮患者可能并发MetS和肥胖，但缺乏显著关联。因此，我们应检查所有肥胖患者，无论其有无皮肤病，以排除代谢综合征。痤疮也会影响患者的生活质量，因此强调需要额外的心理社会咨询。
