细胞焦亡：心血管疾病中的一种新调控机制

Ji Nan, Qi Zhongwen, Wang Yueyao, Yang Xiaoya, Yan Zhipeng, Li Meng, Ge Qihui, Zhang Junping

First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, 300183, People's Republic of China.

National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin, 300193, People's Republic of China.

J Inflamm Res. 2021 Jun 22;14:2647-2666. doi: 10.2147/JIR.S308177. eCollection 2021.

Pyroptosis is a kind of pro-inflammatory cell death. Compared with autophagy and apoptosis, pyroptosis has unique characteristics in morphology and mechanism. Specifically, pyroptosis is a kind of cell lysis mediated by the Gasdermin family, releases inflammatory cytokines IL-1β and IL-18. There are three different forms of mechanism, which are caspase-1-mediated, caspase-4/5/11-mediated and caspase-3-mediated. A large number of studies have proved that pyroptosis is closely related to cardiovascular disease. This paper reviewed the recent progress in the related research on pyroptosis and myocardial infarction, ischemia-reperfusion, atherosclerosis, diabetic cardiomyopathy, arrhythmia, heart failure hypertension and Kawasaki disease. Therefore, we believe that pyroptosis may be a new therapeutic target in the cardiovascular field.

细胞焦亡是一种促炎性细胞死亡。与自噬和凋亡相比，细胞焦亡在形态和机制上具有独特的特征。具体而言，细胞焦亡是一种由Gasdermin家族介导的细胞裂解，释放炎性细胞因子IL-1β和IL-18。存在三种不同形式的机制，即caspase-1介导、caspase-4/5/11介导和caspase-3介导。大量研究证明，细胞焦亡与心血管疾病密切相关。本文综述了细胞焦亡与心肌梗死、缺血再灌注、动脉粥样硬化、糖尿病心肌病、心律失常、心力衰竭、高血压和川崎病相关研究的最新进展。因此，我们认为细胞焦亡可能是心血管领域的一个新的治疗靶点。