Pinzón-Osorio César Augusto, Ávila-Coy Jersson, Gomez Arlen P, Marcela Álvarez-Mira Diana
Department of Animal Health, School of Veterinary Medicine, Universidad Nacional de Colombia, Sede Bogotá, Poultry Research Building, Bogotá DC, Carrera 45 #26-85, Colombia.
Vet Anim Sci. 2021 Jun 6;13:100184. doi: 10.1016/j.vas.2021.100184. eCollection 2021 Sep.
A 28-year-old male harpy eagle () with a history of anorexia, hyporexia, lethargy, and progressive weight loss was found dead and submitted for post-mortem examination. Gross findings include dark brown discolouration of testes and lungs; the testes were bilaterally enlarged, glistening brown-grey to blackish in appearance, firm, smooth, and multilobulated. The lungs contained a mass with similar features to the testicles, irregularly shaped with multiple nodules. Histology of testis showed round, polygonal and pleomorphic cells, containing melanin pigments and a typical eosinophilic vacuole in their cytoplasm and with severe pleomorphism. An immunohistochemistry panel with Melan-A, vimentin, CK AE1/AE/3, MUM-1 and CD-68 were performed, yielding a positive reaction for Melan-A and vimentin. The morphology of the tumour cells, the presence of melanin pigment and the immunoreactivity for Melan-A and vimentin by the cells led to a diagnosis of rhabdoid melanoma. This is the first case of this pathology in the testis with lung metastasis in a harpy eagle.
一只28岁的雄性角雕，有厌食、食欲减退、嗜睡和体重逐渐减轻的病史，被发现死亡并提交进行尸检。大体检查结果包括睾丸和肺呈深褐色变色；睾丸双侧肿大，外观呈闪亮的棕灰色至黑色，质地坚硬、表面光滑且呈多叶状。肺内有一个与睾丸特征相似的肿块，形状不规则，有多个结节。睾丸组织学检查显示有圆形、多边形和多形性细胞，细胞质中含有黑色素和典型的嗜酸性空泡，且具有严重的多形性。进行了Melan-A、波形蛋白、细胞角蛋白AE1/AE/3、MUM-1和CD-68的免疫组织化学检测，结果显示Melan-A和波形蛋白呈阳性反应。肿瘤细胞的形态、黑色素的存在以及细胞对Melan-A和波形蛋白的免疫反应性导致诊断为横纹肌样黑色素瘤。这是角雕睾丸发生这种病理情况并伴有肺转移的首例病例。
