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痴呆患者攻击行为发作期间是否存在特征性自主神经反应?

Is There a Characteristic Autonomic Response During Outbursts of Combative Behavior in Dementia Patients?

作者信息

Deutsch Curtis K, Patnaik Pooja P, Greco Frank A

机构信息

Eunice Kennedy Shriver Center, Department of Psychiatry, University of Massachusetts Medical School, Worcester, MA, USA.

Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ, USA.

出版信息

J Alzheimers Dis Rep. 2021 May 4;5(1):389-394. doi: 10.3233/ADR-210007.

DOI:10.3233/ADR-210007
PMID:34189410
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8203282/
Abstract

We sought to determine whether skin conductance level could warn of outbursts of combative behavior in dementia patients by using a wristband device. Two outbursts were captured and are reported here. Although no physiologic parameter measured by the wristband gave advance warning, there is a common pattern of parasympathetic withdrawal (increased heart rate) followed approximately 30 seconds later by sympathetic activation (increased skin conductance). In the literature, a similar pattern occurs in psychogenic non-epileptic seizures. We hypothesize that similar autonomic responses reflect similarities in pathophysiology and that physical activity may partially account for the time course of skin conductance.

摘要

我们试图通过使用腕带设备来确定皮肤电导率水平是否能够预警痴呆症患者的攻击性行为爆发。我们捕捉到了两次爆发事件并在此报告。尽管腕带测量的生理参数均未给出提前预警,但存在一种共同模式,即副交感神经退缩(心率增加),随后大约30秒后交感神经激活(皮肤电导率增加)。在文献中,类似的模式出现在心因性非癫痫性发作中。我们假设类似的自主神经反应反映了病理生理学上的相似性,并且身体活动可能部分解释了皮肤电导率的时间进程。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cae4/8203282/c6c47441dc52/adr-5-adr210007-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cae4/8203282/959f5611691f/adr-5-adr210007-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cae4/8203282/c6c47441dc52/adr-5-adr210007-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cae4/8203282/959f5611691f/adr-5-adr210007-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cae4/8203282/c6c47441dc52/adr-5-adr210007-g002.jpg

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2
Autonomic nervous system changes detected with peripheral sensors in the setting of epileptic seizures.在癫痫发作的情况下,通过外周传感器检测到自主神经系统变化。
Sci Rep. 2020 Jul 14;10(1):11560. doi: 10.1038/s41598-020-68434-z.
3
Ictal autonomic activity recorded via wearable-sensors plus machine learning can discriminate epileptic and psychogenic nonepileptic seizures.
阿尔茨海默病中激越的新视角:潜在的范式转变
Int J Mol Sci. 2025 Apr 4;26(7):3370. doi: 10.3390/ijms26073370.
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Insight of autonomic dysfunction in CLN3 disease: a study on episodes resembling paroxysmal sympathetic hyperactivity (PSH).CLN3 病自主神经功能障碍的研究:类似发作性交感神经兴奋(PSH)的发作研究。
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Treatment of non-epileptic episodes of anxious, fearful behavior in adolescent juvenile neuronal ceroid lipofuscinosis (CLN3 disease).青少年神经元蜡样脂褐质沉积症(CLN3病)中焦虑、恐惧行为的非癫痫发作的治疗。
Front Neurol. 2023 Sep 12;14:1216861. doi: 10.3389/fneur.2023.1216861. eCollection 2023.
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Distinct Pathogenic Genes Causing Intellectual Disability and Autism Exhibit a Common Neuronal Network Hyperactivity Phenotype.导致智力障碍和自闭症的致病基因表现出共同的神经元网络过度活跃表型。
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