Meyer Heiko, Buhr Annika, Callaerts Patrick, Schiemann Ronja, Wolfner Mariana F, Marygold Steven J
Department of Zoology & Developmental Biology, Osnabrück University, 49076 Osnabrück, Germany.
Laboratory of Behavioral and Developmental Genetics, Department of Human Genetics, KULeuven, University of Leuven, B-3000 Leuven, Belgium.
MicroPubl Biol. 2021 Jun 23;2021. doi: 10.17912/micropub.biology.000410.
The neprilysin (M13) family of metalloendopeptidases comprises highly conserved ectoenzymes that cleave and thereby inactivate many physiologically relevant peptides in the extracellular space. Impaired neprilysin activity is associated with numerous human diseases. Here, we present a comprehensive list and classification of M13 family members in . Seven () genes encode active peptidases, while 21 () genes encode proteins predicted to be catalytically inactive. RNAseq data demonstrate that all 28 genes are expressed during development, often in a tissue-specific pattern. Most Nep proteins possess a transmembrane domain, whereas almost all Nepl proteins are predicted to be secreted.
中性肽链内切酶（M13）金属内肽酶家族由高度保守的胞外酶组成，这些酶可切割并由此使细胞外空间中许多生理相关肽失活。中性肽链内切酶活性受损与多种人类疾病相关。在此，我们给出了……中M13家族成员的完整列表及分类。七个（……）基因编码活性肽酶，而21个（……）基因编码预计无催化活性的蛋白质。RNA测序数据表明，所有28个基因在发育过程中均有表达，且通常呈组织特异性模式。大多数Nep蛋白具有跨膜结构域，而几乎所有Nepl蛋白预计会被分泌。
