Department of Periodontology, Tufts University School of Dental Medicine, One Kneeland Street, Boston, MA, 02111, USA.
Center for Healthcare Organization and Implementation Research, VA Bedford Healthcare System, Bedford, MA, 01730, USA.
Arch Osteoporos. 2021 Jun 29;16(1):105. doi: 10.1007/s11657-021-00970-1.
PURPOSE/INTRODUCTION: Tooth loss has been found to be associated with fractures and osteoporosis. However, the associations between number of teeth with bone mineral density as well as with hip fractures have not been explored in the same study setting.
Data from the cross-sectional National Health and Nutrition Examination Survey (2005-2010, 2013-2014, and 2017-2018) with completed femoral neck bone mineral density (BMD) measurements, osteoporosis questionnaires, and dentition examinations were analyzed. A total of 15,198 participants, with a mean age of 53.9 and diverse ethnicity, males (52%), and females (48%), were analyzed. Multivariate logistic regression analyses for self-reported hip fractures, self-reported osteoporosis, and measured low femoral BMD accounting for traditional risk factors were tested for the total number of natural teeth (NoT) present, or by NoT in the anterior or posterior segments.
Subjects with fewer natural teeth present were more likely to report a hip fracture, osteoporosis, or having lower levels of femoral neck BMD. With one additional tooth present in the mouth, there was a decreased association with self-reported hip fracture [OR(95%CI) = 0.98(0.96-0.99); P = 0.005] or with less likelihood of having low femoral neck BMD [OR(95%CI) = 0.99(0.97-1.00); P = 0.007].
With the limitation of the cross-sectional study design, results should be interpreted cautiously, yet our analyses point to an association between a decreased number of natural teeth present and self-reported hip fractures or low femoral neck BMD. The number of teeth present could be potentially utilized for assessing risks of hip fracture and osteoporosis. Future research is needed to validate our findings.
目的/引言：已有研究发现，牙齿缺失与骨折和骨质疏松症有关。然而，在同一研究环境中，牙齿数量与骨密度以及髋部骨折之间的关联尚未得到探索。
对来自横断面全国健康和营养检查调查（2005-2010 年、2013-2014 年和 2017-2018 年）的数据进行了分析，这些数据包含了股骨颈骨密度（BMD）测量、骨质疏松症问卷和牙齿检查结果。共分析了 15198 名参与者，平均年龄为 53.9 岁，种族多样，男性占 52%，女性占 48%。针对总牙数（NoT）、前牙段或后牙段的 NoT，通过多变量逻辑回归分析，检验了传统危险因素校正后的自我报告髋部骨折、自我报告骨质疏松症和测量的股骨颈低 BMD 与 NoT 的关系。
存在较少天然牙齿的受试者更有可能报告髋部骨折、骨质疏松症或股骨颈 BMD 水平较低。口腔中每增加一颗牙齿，与自我报告的髋部骨折的关联就会降低[比值比（95%可信区间）= 0.98（0.96-0.99）；P=0.005]，或者发生股骨颈低 BMD 的可能性就会降低[比值比（95%可信区间）= 0.99（0.97-1.00）；P=0.007]。
由于横断面研究设计的限制，结果应谨慎解读，但我们的分析指出，存在的天然牙齿数量减少与自我报告的髋部骨折或股骨颈低 BMD 之间存在关联。存在的牙齿数量可能可用于评估髋部骨折和骨质疏松症的风险。需要进一步的研究来验证我们的发现。
