Department of Nuclear Medicine, Molecular Imaging & Therapeutic Medicine Research Center, Jeonbuk National University Medical School and Hospital, Jeonju, 54907, Korea.
Research Institute of Clinical Medicine, Jeonbuk National University-Biomedical Research Institute, Jeonbuk National University Hospital, Jeonju, 54907, Korea.
Chem Asian J. 2021 Aug 16;16(16):2155-2167. doi: 10.1002/asia.202100399. Epub 2021 Jul 9.
Carbon-fluorine bond formations have received a lot of attention because organofluorine compounds are widely used in pharmaceutical, agricultural, and materials science applications. In particular, the incorporation of fluorine-18, which is a commonly used radioisotope for radiopharmaceuticals for positron emission tomography (PET), a molecular imaging tool for the visualization of biochemical events, human metabolism processes, and the measurement and diagnosis of diseases in humans, plays a crucial role in clinical and preclinical studies. Several synthetic methodologies for carbon-fluorine-18 bond formation have been developed. However, conventional fluorination methods have some remaining drawbacks such as the high temperature and basic environment. Photo-induced catalysis is an emerging technique that allow chemists to achieve the synthesis of target molecular architectures under mild conditions. Moreover, several radiofluorination strategies have been developed via photocatalysis. In this review, we focused on describing recent advances in the field of light-mediated radiofluorination.
碳-氟键的形成受到了广泛关注，因为有机氟化合物在制药、农业和材料科学等领域有广泛的应用。特别是，氟-18 的引入在正电子发射断层扫描（PET）等放射性药物中起着至关重要的作用，这是一种用于可视化生化事件、人类代谢过程以及测量和诊断人类疾病的分子成像工具。已经开发了几种用于形成碳-氟-18 键的合成方法。然而，传统的氟化方法仍存在一些缺点，如高温和碱性环境。光诱导催化是一种新兴技术，使化学家能够在温和的条件下实现目标分子结构的合成。此外，还通过光催化开发了几种放射性氟化策略。在这篇综述中，我们重点描述了光介导放射性氟化领域的最新进展。
