Jansson T, Kristiansson B, Qirbi A
Department of Physiology, Gothenburg University, Sweden.
J Ethnopharmacol. 1988 May-Jun;23(1):19-26. doi: 10.1016/0378-8741(88)90111-0.
In order to investigate effects of khat chewing on uteroplacental blood flow, eight awake, chronically catheterized guinea pigs were fed 2.2 g khat leaves/kg in late pregnancy and regional blood flows were measured with the microsphere technique. Seven animals fed with aspen leaves in the same amounts served as controls. The mean concentration of (+)-norpseudoephedrine in urine 3 h after the end of the feeding was 4.6 micrograms/ml in the khat-fed group with no detectable amounts in the controls. Placental blood flow was reduced by 10% 75 min and by 24% 180 min after khat feeding. Since the khat dose used gave urinary concentrations of (+)-norpseudoephedrine of the same magnitude as those reported in khat chewing women, khat chewing in pregnancy may reduce placental blood flow and impair fetal growth.
为了研究咀嚼巧茶对子宫胎盘血流的影响，选取8只清醒且长期插管的豚鼠，在妊娠后期给它们喂食2.2克巧茶叶/千克体重，并用微球技术测量局部血流。另外7只喂食等量白杨叶的动物作为对照。喂食结束3小时后，巧茶喂养组尿液中（+）-去甲伪麻黄碱的平均浓度为4.6微克/毫升，而对照组未检测到该物质。喂食巧茶后75分钟，胎盘血流量减少了10%，180分钟后减少了24%。由于所用巧茶剂量使尿液中（+）-去甲伪麻黄碱的浓度与报道的咀嚼巧茶的女性体内浓度相当，因此孕期咀嚼巧茶可能会减少胎盘血流量并影响胎儿生长。
