利托君对未麻醉妊娠豚鼠子宫胎盘血流及心输出量分布的影响。

Effect of ritodrine on uteroplacental blood flow and cardiac output distribution in unanesthetized pregnant guinea pigs.

作者信息

van de Walle A F, Martin C B

出版信息

Am J Obstet Gynecol. 1986 Jan;154(1):189-94. doi: 10.1016/0002-9378(86)90423-0.

Abstract

The effects of ritodrine, 15 micrograms X min-1 X kg-1 infused intravenously for 2 hours, on cardiac output distribution and uteroplacental blood flow were investigated in 10 chronically catheterized guinea pigs between 57 and 63 days of pregnancy. Ritodrine produced an average 29% increase in cardiac output, three quarters of which was distributed to the carcass and myocardium. Absolute placental blood flow decreased by 10%, and the placental fraction of cardiac output decreased by one third. Uteroplacental vascular resistance increased by 41% during ritodrine infusion. The proportional changes in placental blood flow were positively correlated and those in placental vascular resistance negatively correlated with the change in cardiac output.

摘要

在10只妊娠57至63天、长期插管的豚鼠中，研究了静脉输注利托君（15微克/分钟·千克，持续2小时）对心输出量分布和子宫胎盘血流量的影响。利托君使心输出量平均增加29%，其中四分之三分布到躯体和心肌。胎盘绝对血流量减少10%，心输出量的胎盘部分减少三分之一。输注利托君期间，子宫胎盘血管阻力增加41%。胎盘血流量的比例变化与心输出量变化呈正相关，胎盘血管阻力的比例变化与心输出量变化呈负相关。