MacArthur Robert B, Bentur Ohad S, MacArthur Ian C, Bartoo Anna S, Capozzi Donna L, Christensen Jason A, Johnson Amber L, Patel Kuldip, Coller Barry S
Rockefeller University Hospital Pharmacy, The Rockefeller University, New York, NY, USA.
Allen and Frances Adler Laboratory of Blood and Vascular Biology, The Rockefeller University, New York, NY, USA.
J Clin Transl Sci. 2021 Feb 18;5(1):e108. doi: 10.1017/cts.2021.13.
In March 2020, academic medical center (AMC) pharmacies were compelled to implement practice changes in response to the COVID-19 pandemic. These changes were described by survey data collected by the Clinical and Translational Science Awards (CTSA) program which were interpreted by a multi-institutional team of AMC pharmacists and physician investigators.
The CTSA program surveyed 60 AMC pharmacy departments. The survey included event timing, impact on pharmacy services, and corrective actions taken.
Almost all departments (98.4%) reported at least one disruption. Shortages of personal protective equipment (PPE) were common (91.5%) as were drug shortages (66.0%). To manage drug shortages, drug prioritization protocols were utilized, new drug supply vendors were identified (79.3%), and onsite compounding was initiated. PPE shortages were managed by incorporating the risk mitigation strategies recommended by FDA and others. Research pharmacists supported new clinical research initiatives at most institutions (84.0%), introduced use of virtual site visits, and shipped investigational drugs directly to patients. Some pharmacies formulated novel investigational products for clinical trial use. Those AMC pharmacies within networked health systems assisted partner rural and inner-city hospitals by sourcing commercial and investigational drugs to alleviate local disease outbreaks and shortages in underserved populations. Pharmacy-based vaccination practice was expanded to include a wider range of pediatric and adult vaccines.
The COVID-19 pandemic radically altered hospital pharmacy practice. By adopting innovative methods and adapting to regulatory imperatives, pharmacies at CTSA sites played an extremely important role supporting continuity of care and collaborating on critical clinical research initiatives.
2020年3月，学术医疗中心（AMC）药房被迫因应2019冠状病毒病疫情实施业务变革。临床与转化科学奖（CTSA）项目收集的调查数据描述了这些变革，由AMC药剂师和医师研究人员组成的多机构团队对这些数据进行了解读。
CTSA项目对60个AMC药房部门进行了调查。调查内容包括事件发生时间、对药房服务的影响以及采取的纠正措施。
几乎所有部门（98.4%）都报告至少有一次业务中断。个人防护装备（PPE）短缺很常见（91.5%），药品短缺情况也很常见（66.0%）。为应对药品短缺，采用了药品优先排序方案，确定了新的药品供应商（79.3%），并开始进行现场配制。通过采用美国食品药品监督管理局（FDA）和其他机构推荐的风险缓解策略来应对PPE短缺问题。研究药剂师在大多数机构（84.0%）支持新的临床研究项目，引入了虚拟现场访视的使用，并将研究用药物直接运送给患者。一些药房配制了用于临床试验的新型研究产品。那些隶属于联网医疗系统的AMC药房通过采购商业和研究用药物，协助农村和市中心的合作医院缓解当地疾病暴发以及服务欠缺人群的药品短缺问题。以药房为基础的疫苗接种业务得到扩展，涵盖了更广泛的儿科和成人疫苗。
2019冠状病毒病疫情从根本上改变了医院药房的业务。通过采用创新方法并适应监管要求，CTSA站点的药房在支持医疗服务连续性以及参与关键临床研究项目合作方面发挥了极其重要的作用。
