活动性溃疡性结肠炎患者在开始使用类固醇之前进行粒细胞和单核细胞吸附性血液成分单采术有效性的探索性研究（EXPECT研究）：一项多中心前瞻性临床试验
Exploratory Study of the Effectiveness of Granulocyte and Monocyte Adsorptive Apheresis Before Initiation of Steroids in Patients With Active Ulcerative Colitis (EXPECT Study): A Multicenter Prospective Clinical Trial.
作者信息
Kakimoto Kazuki, Matsuura Minoru, Fukuchi Takumi, Hongo Hitoshi, Kimura Tsuguhiro, Aoyama Nobuo, Okuda Yorihide, Aomatsu Kazuki, Kamata Noriko, Yokoyama Yoko, Mizuno Chiemi, Inoue Takuya, Miyazaki Takako, Nakamura Shiro, Higuchi Kazuhide, Nakase Hiroshi
机构信息
2nd Department of Internal Medicine, Osaka Medical College, Takatsuki, Osaka, Japan.
Department of Gastroenterology and Hepatology, Kyorin University School of Medicine, Mitaka, Tokyo, Japan.
出版信息
Crohns Colitis 360. 2020 Sep 23;2(4):otaa073. doi: 10.1093/crocol/otaa073. eCollection 2020 Oct.
BACKGROUND
Granulocyte and monocyte adsorptive apheresis (GMA) has been used for therapy of steroid-dependent/refractory ulcerative colitis (UC). The aim of this study was to investigate the effectiveness of GMA in UC patients not receiving steroids.
METHODS
We conducted a single-arm, open-label, and multicenter prospective clinical trial. UC patients who had insufficient responses to 5-aminosalicylic acid received GMA twice a week for 5 weeks.
RESULTS
The response rate of all patients was 58.2% (39/67). Of the 39 patients who achieved a response, 74.4% achieved endoscopically confirmed mucosal healing.
CONCLUSIONS
GMA shows effectiveness in inducing remission in UC patients not receiving steroid.
背景
粒细胞和单核细胞吸附性血液成分单采术（GMA）已用于类固醇依赖/难治性溃疡性结肠炎（UC）的治疗。本研究的目的是调查GMA对未接受类固醇治疗的UC患者的有效性。
方法
我们进行了一项单臂、开放标签的多中心前瞻性临床试验。对5-氨基水杨酸反应不足的UC患者每周接受2次GMA治疗，共5周。
结果
所有患者的缓解率为58.2%（39/67）。在39例获得缓解的患者中，74.4%实现了内镜确认的黏膜愈合。
结论
GMA对未接受类固醇治疗的UC患者诱导缓解有效。
Zotero 插件