Voronina T A, Nerobkova L N, Garibova T L, Dikova M, Nikolov R, Nikolova M, Markina N V
Pharmacological Research Institute, USSR Academy of Medical Sciences, Moscow.
Methods Find Exp Clin Pharmacol. 1988 Jul;10(7):431-5.
The anti-amnestic action of nicergoline was studied using the following experimental methods for learning and memory impairment, based on passive avoidance response: amnesia induced by maximal electroshock in mice, scopolamine-induced amnesia in mice and amnesia by paradoxical sleep deprivation in rats. Piracetam, meclofenoxate, pyritinol, deanol and phenazepam were used as reference drugs. The results show that nicergoline demonstrates well-expressed anti-amnestic effect manifested by reducing the amnestic effect of maximal electroshock, scopolamine or paradoxical sleep deprivation, its effect being equal to or more pronounced than piracetam, meclofenoxate, pyritinol, deanol and phenazepam.
基于被动回避反应，采用以下学习和记忆损伤的实验方法，研究了尼麦角林的抗遗忘作用：小鼠最大电休克诱导的遗忘、东莨菪碱诱导的小鼠遗忘以及大鼠反常睡眠剥夺诱导的遗忘。吡拉西坦、氯酯醒、吡硫醇、二甲氨基乙醇和非那西泮用作参比药物。结果表明，尼麦角林表现出明显的抗遗忘作用，表现为降低最大电休克、东莨菪碱或反常睡眠剥夺的遗忘作用，其效果与吡拉西坦、氯酯醒、吡硫醇、二甲氨基乙醇和非那西泮相当或更显著。
