Centre for Applied Physics and Radiation Technologies, School of Engineering and Technology, Sunway University, Selangor, Malaysia.
Department of Physics, The University of Jordan, Amman, Jordan.
Br J Radiol. 2021 Aug 1;94(1124):20201265. doi: 10.1259/bjr.20201265. Epub 2021 Jun 30.
Infection, the invasion of pathogenic microorganisms and viruses, causes reactive inflammation mediated by endogenous signals, with influx of leucocytes with distinct properties and capable of mounting a cellular or antibody response. Different forms of inflammation may also occur in response to tumours, in allergy and autoimmune disorders. Pneumonia, respiratory tract infection and septic shock for instance can arise as serious complications of the Covid-19 virus. While radiotherapy has been most widely used to control malignant tumours, it has also been used for treatment of non-malignant diseases, including acute and chronic inflammation in situations where anti-inflammatory drugs may be ineffective or contraindicated. The present review examines the history and prospects for low-dose anti-inflammatory radiation treatments, the present interest largely being motivated by the increased incidence of pulmonary disease associated Covid-19 infections. Evidence in support of the suggested efficacy are covered, together with an appraisal of one of the number of potential convenient sources that could complement external beam arrangements.
感染,即病原微生物和病毒的入侵,会引起内源性信号介导的反应性炎症,伴有具有不同特性的白细胞流入,并能引发细胞或抗体反应。炎症也可能以不同的形式发生,如肿瘤、过敏和自身免疫性疾病。例如,肺炎、呼吸道感染和败血症性休克可能是新冠病毒的严重并发症。虽然放射疗法最广泛地用于控制恶性肿瘤,但它也用于治疗非恶性疾病,包括在抗炎药物可能无效或禁忌的情况下,治疗急性和慢性炎症。本综述探讨了低剂量抗炎辐射治疗的历史和前景,目前的兴趣主要是由与新冠病毒感染相关的肺部疾病发病率增加所驱动。本文涵盖了对所建议疗效的证据支持,以及对许多潜在的便利来源之一的评估,这些来源可以补充外照射设备。