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加拿大队列中机器人辅助腹腔镜子宫肌瘤剔除术后的生育和妊娠结局。

Fertility and Pregnancy Outcomes After Robotic-assisted Laparoscopic Myomectomy in a Canadian Cohort.

机构信息

Department of Obstetrics and Gynaecology, University of Toronto (Drs. Goldberg, McCaffrey, and Kives).

Department of Obstetrics and Gynaecology, University of Toronto (Drs. Goldberg, McCaffrey, and Kives); Department of Obstetrics and Gynaecology, St. Michael's Hospital (Drs. McCaffrey, Amjad and Kives), Toronto, Ontario, Canada.

出版信息

J Minim Invasive Gynecol. 2022 Jan;29(1):72-76. doi: 10.1016/j.jmig.2021.06.015. Epub 2021 Jun 27.

Abstract

STUDY OBJECTIVE

Myomectomy is the gold standard treatment for patients with symptomatic fibroids who desire fertility preservation. Given the relatively recent application of robotic surgery in the field of gynecology, there is only a small amount of data describing fertility outcomes after robotic-assisted laparoscopic myomectomy (RALM). The objective of this study was to determine the pregnancy rate in patients trying to conceive after RALM.

DESIGN

A single-center, retrospective case series.

SETTING

Department of Obstetrics and Gynecology, St. Michael's Hospital, Toronto, Ontario, Canada.

PATIENTS

All patients who underwent RALM between October 2008 and September 2015 and who consented to a telephone interview were included.

INTERVENTION

None. The primary outcome was pregnancy rate after RALM. Secondary outcomes included whether patients underwent fertility treatment, rate of live births after RALM, rate of spontaneous abortion mode of delivery in pregnancies following RALM, obstetric complications, and symptoms experienced postoperatively.

MEASUREMENTS AND MAIN RESULTS

A total of 123 patients underwent RALM between 2008 and 2015. Of them, 101 consented to be interviewed. Average age ± standard deviation was 34.4 ± 4.4 years. Average myoma size was 8.9 ± 2.2 cm. Of all myomas, 64 (63.4%) were intramural, 35 (34.7%) were subserosal, and 2 (2%) were submucosal according to preoperative imaging. The pregnancy rate after RALM was 42/60 (70.0%). Three additional patients became pregnant who were not trying to conceive. Of the 45 patients who became pregnant, 38 (84.4%) successfully delivered or were pregnant at the time of data collection.

CONCLUSION

The pregnancy rate after RALM was 70.0%, which is similar to that reported in previous studies. Future research should aim to conduct larger, prospective studies investigating fertility outcomes after RALM and should aim to identify variables that predict pregnancy.

摘要

研究目的

对于希望保留生育能力的有症状肌瘤患者,肌瘤切除术是金标准治疗方法。鉴于机器人手术在妇科领域的应用相对较新,仅有少量数据描述了机器人辅助腹腔镜肌瘤切除术(RALM)后的生育结局。本研究的目的是确定 RALM 后尝试怀孕的患者的妊娠率。

设计

单中心回顾性病例系列。

地点

加拿大安大略省多伦多市圣迈克尔医院妇产科。

患者

纳入 2008 年 10 月至 2015 年 9 月间接受 RALM 并同意接受电话访谈的所有患者。

干预

无。主要结局是 RALM 后的妊娠率。次要结局包括患者是否接受了生育治疗、RALM 后的活产率、RALM 后妊娠的自然流产方式、产科并发症以及术后症状。

测量和主要结果

共有 123 名患者于 2008 年至 2015 年间接受了 RALM。其中,101 名同意接受采访。平均年龄±标准差为 34.4±4.4 岁。平均肌瘤大小为 8.9±2.2cm。根据术前影像学检查,所有肌瘤中 64 个(63.4%)为壁内肌瘤,35 个(34.7%)为浆膜下肌瘤,2 个(2%)为黏膜下肌瘤。RALM 后的妊娠率为 42/60(70.0%)。另外 3 名未尝试怀孕的患者怀孕。在 45 名怀孕的患者中,38 名(84.4%)成功分娩或在数据收集时怀孕。

结论

RALM 后的妊娠率为 70.0%,与之前的研究报告相似。未来的研究应旨在进行更大规模的前瞻性研究,以调查 RALM 后的生育结局,并应旨在确定预测妊娠的变量。

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