Instituto de Investigación en Ciencias Médicas, Departamento de Clínicas, División de Ciencias Biomédicas, Centro Universitario de los Altos, Universidad de Guadalajara, Tepatitlán de Morelos, Jalisco, México.
Consultorio privado, Aguascalientes, México.
J Stomatol Oral Maxillofac Surg. 2022 Jun;123(3):e1-e9. doi: 10.1016/j.jormas.2021.06.015. Epub 2021 Jun 27.
The aim of this meta-analysis was to assess the analgesic efficacy and adverse effects of celecoxib compared to non-opioid drugs after third molar surgery. A search in PubMed and Google Scholar was performed to identify clinical trials, and then, the Cochrane Collaboration tool was used to assess the risk of bias for all clinical trials. Studies without any high-risk of bias were included in the statistical analysis. The data extraction included the pain intensity measured by the visual analogue scale (VAS), the number of patients using rescue analgesics and adverse effects of gastric (nausea and vomiting), and nervous (dizziness and headache) systems. Data were analyzed using the Review Manager Software 5.3 for Windows and the Risk Reduction Calculator. The visual analog scale, total pain relief, and the number of patients who needed rescue analgesics showed statistical significance. Moreover, celecoxib had a lower frequency of nausea and vomiting compared with ibuprofen. In conclusion, celecoxib was more effective than acetaminophen and ibuprofen for pain control after third molar surgery.
本荟萃分析旨在评估塞来昔布与非阿片类药物相比在第三磨牙手术后的镇痛效果和不良反应。通过在 PubMed 和 Google Scholar 中进行检索，确定了临床试验，并使用 Cochrane 协作工具评估了所有临床试验的偏倚风险。没有任何高偏倚风险的研究被纳入统计分析。数据提取包括视觉模拟评分（VAS）测量的疼痛强度、使用解救镇痛药的患者数量以及胃（恶心和呕吐）和神经（头晕和头痛）系统的不良反应。使用 Review Manager Software 5.3 for Windows 和 Risk Reduction Calculator 对数据进行分析。视觉模拟评分、总疼痛缓解和需要解救镇痛药的患者数量均具有统计学意义。此外，塞来昔布的恶心和呕吐发生率低于布洛芬。总之，塞来昔布在控制第三磨牙手术后疼痛方面比醋氨酚和布洛芬更有效。
