Toyloy M, Tresch N, Raetz K, Dennler M, Körner M, Meier V S, Rohrer Bley C
Abteilung Radio-Onkologie, Departement für Kleintiere, Vetsuisse-Fakultät, Universität Zürich.
Bessy's Kleintierklinik, Watt/Regensdorf, Schweiz.
Schweiz Arch Tierheilkd. 2021 Jul;163(7):505-513. doi: 10.17236/sat00311.
This case report describes a 12-year-old female spayed mixed-breed dog referred for treatment of a large, inoperable hepatocellular carcinoma. A computed tomography (CT) scan confirmed the previous ultrasonographic and laparoscopic findings of a large, lobulated, poorly defined mass on the left and central aspect of the liver. Multiple biopsies confirmed the diagnosis of hepatocellular carcinoma. Due to the large extent of the tumor, the vascular association to the Vena cava caudalis and the associated high risk of intraoperative bleeding, a resection of the mass was refrained from and a radiotherapeutic treatment was chosen. The dog underwent radiation therapy (RT) with a 6MV linear accelerator with 5×6 Gy, total dose 30 Gy. In the follow up examinations three months and one year after therapy, the dog presented in normal condition and had normal Alanine-amino-transferase (ALT) and alkaline phosphatase (AP). The tumor size measured in the CT-examinations decreased by 61% and 90%, respectively. Two years after radiation therapy the dog has a normal general condition and liver enzymes are within the normal limits.
本病例报告描述了一只12岁已绝育的混血雌性犬，因患有无法手术切除的大型肝细胞癌前来接受治疗。计算机断层扫描（CT）证实了先前超声检查和腹腔镜检查的结果，即在肝脏左侧和中央区域存在一个大型、分叶状、边界不清的肿块。多次活检确诊为肝细胞癌。由于肿瘤范围较大、与尾腔静脉的血管关联以及术中出血的高风险，未进行肿块切除，而是选择了放射治疗。这只犬使用6兆伏直线加速器接受了放射治疗（RT），剂量为5×6 Gy，总剂量30 Gy。在治疗后三个月和一年的随访检查中，这只犬状况正常，丙氨酸氨基转移酶（ALT）和碱性磷酸酶（AP）也正常。CT检查测量的肿瘤大小分别减少了61%和90%。放射治疗两年后，这只犬总体状况正常，肝酶在正常范围内。
