J Am Vet Med Assoc. 2021 Aug 15;259(4):392-395. doi: 10.2460/javma.259.4.392.
A 14-year-old 5.6-kg (12.3-lb) castrated male Toy Poodle was evaluated because of high serum activities of alkaline phosphatase and alanine aminotransferase and the presence of a hepatic mass.
Abdominal CT revealed a large (approx 6.8 × 7.1 × 6.5-cm) soft tissue mass along the midline of the liver. The mass either originated from the papillary process of the caudate lobe or the left medial liver lobe.
A partial liver lobectomy was performed, and approximately a third of the mass was successfully removed and submitted for histologic examination. Consultation with the oncology service was advised to determine whether radiation therapy could be used to treat the residual disease. On 5 consecutive days, the dog underwent imaging-guided intensity-modulated radiotherapy-stereotactic body radiation therapy (4 Gy/treatment) with a simultaneous integrated boost to the center of the tumor. The dog received a base dose of 20 Gy that was then boosted to 28 Gy. In the 10-month period after completion of radiation therapy, the hepatocellular mass continued to decrease in size, and overall improvements in the dog's serum liver enzyme abnormalities were evident.
There are few treatment options for dogs with incompletely excised hepatocellular carcinomas. On the basis of the positive outcome in this case, radiation therapy could be useful following incomplete surgical removal of hepatocellular carcinomas in dogs.
一只 14 岁、5.6 公斤（12.3 磅）已去势的雄性玩具贵宾犬，因碱性磷酸酶和丙氨酸氨基转移酶血清活性升高和存在肝肿块而接受评估。
腹部 CT 显示肝脏中线附近有一个大（约 6.8×7.1×6.5 厘米）的软组织肿块。该肿块源自尾叶的乳突或左内侧肝叶。
进行了部分肝叶切除术，成功切除了约三分之一的肿块，并进行了组织学检查。建议咨询肿瘤学服务，以确定是否可以使用放射疗法来治疗残留疾病。在连续 5 天内，该犬接受了成像引导的强度调制放疗-立体定向体部放疗（4Gy/次），同时对肿瘤中心进行同步整合增敏。该犬接受了 20Gy 的基础剂量，然后增加到 28Gy。在放射治疗完成后的 10 个月期间，肝细胞肿块继续缩小，犬的血清肝酶异常整体得到改善。
对于未完全切除的肝细胞癌犬，治疗选择有限。基于该病例的良好结果，对于未完全切除的犬肝细胞癌，放射治疗可能是有用的。
