启动新生儿重症监护病房母乳库的短期结果：一项回顾性研究。

Short-term Outcomes of Launching Mother's Milk Bank in Neonatal Intensive Care Unit: A Retrospective Study.

机构信息

Paediatric Health Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.

Physical Medicine and Rehabilitation Research Centre, Aging Research Institute, Tabriz University of Medical Sciences, Tabriz, Iran.

出版信息

Arch Iran Med. 2021 May 1;24(5):397-404. doi: 10.34172/aim.2021.57.

DOI:10.34172/aim.2021.57

PMID:34196205

Abstract

BACKGROUND

The WHO and UNICEF have suggested pasteurized donor milk (PDM) as the best alternative for infants who do not receive enough milk from their mothers. This study aimed to assess the short-term outcomes of launching the first mother's milk bank in North-West of Iran.

METHODS

The present retrospective study included 366 premature infants (181 pre-launch and 185 post-launch) who were hospitalized in Al-Zahra Hospital of Tabriz, Iran. The study included infants with birth weight ˂2000 g and/or gestation age ˂32 weeks who were born before and after the launch of mother's milk bank. Frequency of necrotizing enterocolitis (NEC), retinopathy of prematurity (ROP), late onset sepsis (LOS) and mortality rate were compared. Data were analyzed using SPSS 23 with the chi-square test, Fisher exact test, independent t test, and logistic regression test.

RESULTS

In total, NEC grade ≥2 was reported in 9 cases; 8 cases (4.41%) in pre-launch and one case (0.54%) in post-launch (adjusted OR=0.091; 95% CI=0.010 to 0.849, =0.035). ROP was reported in 21 cases in two groups. Nineteen cases (10.5%) belonged to the pre-launch group and 2 cases (3.7%) to the post-launch group (adjusted OR=0.105; 95% CI=0.022 to 0.488, =0.004). LOS was also found in 17 cases (9.39%) in the pre-launch group and 4 cases (2.16%) in the post-launch period, suggesting a significant difference between the two groups (adjusted OR=0.297; 95%CI=0.089 to 0.995, =0.049). There was no significant difference in mortality of infants during hospitalization between the two groups (=0.789); however, it was decreased from 15 to 8.

CONCLUSION

Launching the human milk bank significantly improved the outcomes of premature infants.

摘要

背景

世界卫生组织和儿基会建议使用巴氏消毒捐献奶（PDM）作为无法从母亲那里获得足够母乳的婴儿的最佳替代品。本研究旨在评估在伊朗西北部首次推出母乳银行的短期结果。

方法

本回顾性研究纳入了 366 名早产儿（181 名预启动前和 185 名启动后），他们在伊朗大不里士 Al-Zahra 医院住院。该研究包括出生体重<2000g 和/或胎龄<32 周的婴儿，他们出生于母乳银行启动之前和之后。比较坏死性小肠结肠炎（NEC）、早产儿视网膜病变（ROP）、晚发性败血症（LOS）和死亡率的发生率。使用 SPSS 23 进行数据分析，采用卡方检验、Fisher 确切检验、独立 t 检验和逻辑回归检验。

结果

共有 9 例报告 NEC 分级≥2；8 例（4.41%）发生在预启动前，1 例（0.54%）发生在启动后（调整后的 OR=0.091；95%CI=0.010 至 0.849，=0.035）。两组均有 21 例报告 ROP。19 例（10.5%）属于预启动前组，2 例（3.7%）属于启动后组（调整后的 OR=0.105；95%CI=0.022 至 0.488，=0.004）。预启动前组 LOS 为 17 例（9.39%），启动后组为 4 例（2.16%），两组差异有统计学意义（调整后的 OR=0.297；95%CI=0.089 至 0.995，=0.049）。两组患儿住院期间死亡率无统计学差异（=0.789）；但从 15%降至 8%。