Tout S, Ashwell K, Stone J
Department of Anatomy, University of Sydney, N.S.W., Australia.
Neurosci Lett. 1988 Aug 1;90(3):241-7. doi: 10.1016/0304-3940(88)90196-6.
We have examined the development of astrocytes in the albino rabbit retina, using antibodies to glial fibrillary acidic protein (GFAP) and vimentin. Vimentin immunoreactive (vimentin+) astrocyte-like cells first appear at the 24th postconceptional day (24 PCD), in a pattern similar to that of the adult. GFAP immunoreactivity was first detected in astrocytes at the 29 PCD, in a similar pattern. Vessels enter the retina from 29 PCD. The presence of astrocytes in a mature distribution prior to the ingrowth of vessels indicates that astrocytes are not dependent on the vessels for their early positioning and differentiation. In contrast with the rat and cat, we found no evidence of migration of astrocytes into the rabbit retina from the optic nerve.
我们利用针对胶质纤维酸性蛋白（GFAP）和波形蛋白的抗体，研究了白化兔视网膜中星形胶质细胞的发育情况。波形蛋白免疫反应性（波形蛋白阳性）的星形胶质细胞样细胞最早在受孕后第24天（24 PCD）出现，其分布模式与成年兔相似。GFAP免疫反应性最早在29 PCD时在星形胶质细胞中检测到，分布模式类似。血管从29 PCD开始进入视网膜。在血管长入之前，星形胶质细胞就已呈成熟分布，这表明星形胶质细胞的早期定位和分化并不依赖于血管。与大鼠和猫不同，我们没有发现星形胶质细胞从视神经迁移到兔视网膜的证据。
